ReviewImmunology and cell biology2011
Mice with human immune system components as in vivo models for infections with human pathogens.
Review in Immunology and cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Human whole blood influences the expression of Acinetobacter baumannii genes related to translation and siderophore production.PloS one · 2025Article
- Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: pre-clinical updates.Oncotarget · 2022Review
- Brain-on-a-chip: A history of development and future perspective.Biomicrofluidics · 2019Article
- A Cinematic View of Tissue Microbiology in the Live Infected Host.Microbiology spectrum · 2019Review
- CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo.PLoS pathogens · 2019Article
- Advanced model systems and tools for basic and translational human immunology.Genome medicine · 2018Review
- Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice?Human reproduction update · 2018Review
- The latest animal models of ovarian cancer for novel drug discovery.Expert opinion on drug discovery · 2018Review
- Humanized Mice Are Instrumental to the Study ofFrontiers in immunology · 2018Review
- Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins.Immunology · 2017Article
- Influence of Genetic Background on Hematologic and Histopathologic Alterations during Acute Granulocytic Anaplasmosis in 129/SvEv and C57BL/6J Mice Lacking Type I and Type II Interferon Signaling.Comparative medicine · 2017Article
- Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2016Article
- Fidelity in Animal Modeling: Prerequisite for a Mechanistic Research Front Relevant to the Inflammatory Incompetence of Acute Pediatric Malnutrition.International journal of molecular sciences · 2016Review
- Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.AIDS research and human retroviruses · 2016Article
- Vaccine targets against Moraxella catarrhalis.Expert opinion on therapeutic targets · 2016Review
- Limitations of CurrentMedical sciences (Basel, Switzerland) · 2015Review
- Infectious mononucleosis.Clinical & translational immunology · 2015Review
- Infectious Mononucleosis.Current topics in microbiology and immunology · 2015Review
- The future potential for cocaine vaccines.Expert opinion on biological therapy · 2014Review
- Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection.Cell reports · 2013Article
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5 authors.
Funding
Abstract
Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leukocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.