ArticlePlant signaling & behavior2011
A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction.
Article in Plant signaling & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The front line of defence: a meta-analysis of apoplastic proteases in plant immunity.Journal of experimental botany · 2021Pooled it
- The pathogenicity of Plasmopara viticola: a review of evolutionary dynamics, infection strategies and effector molecules.BMC plant biology · 2024Review
- Supplementation of the Plant Conditioner ELICE VakcinaPlants (Basel, Switzerland) · 2023Article
- Phytopathogenic oomycetes: a review focusing on Phytophthora cinnamomi and biotechnological approaches.Molecular biology reports · 2020Review
- Effectors of Phytophthora pathogens are powerful weapons for manipulating host immunity.Planta · 2019Review
- Manipulation of Phytohormone Pathways by Effectors of Filamentous Plant Pathogens.Frontiers in plant science · 2019Review
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
- A cathepsin F-like peptidase involved in barley grain protein mobilization, HvPap-1, is modulated by its own propeptide and by cystatins.Journal of experimental botany · 2012Article
- Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathogen defense.PLoS genetics · 2012Article
- A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oomycete pathogen Phytophthora infestans secretes cystatin-like effector proteins (EPICs) that inhibit secreted host proteases during infection. We recently found that the C14 protease is a relevant target of EPICs and that this protease is under diversifying selection in wild potato species with which P. infestans has coevolved. Here we generated a model of the EPIC-C14 complex based on cystatin-papain crystal structures and discovered three regions where variant residues in C14 might be the result of an arms race between enzyme and inhibitor at the plant-pathogen interface.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.