ArticlePhysical biology2011
Micromechanics of human mitotic chromosomes.
Article in Physical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Independence of centromeric and pericentromeric chromatin stability on CCAN components.Molecular biology of the cell · 2025Article
- The material properties of mitotic chromosomes.Current opinion in structural biology · 2023Review
- Nonlinear mechanics of human mitotic chromosomes.Nature · 2022Article
- Chromosome disentanglement driven via optimal compaction of loop-extruded brush structures.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Effects of altering histone posttranslational modifications on mitotic chromosome structure and mechanics.Molecular biology of the cell · 2019Article
- Condensin controls mitotic chromosome stiffness and stability without forming a structurally contiguous scaffold.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
- Mitotic tethers connect sister chromosomes and transmit "cross-polar" force during anaphase A of mitosis in PtK2 cells.Biomedical optics express · 2017Article
- Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Laser microsurgery reveals conserved viscoelastic behavior of the kinetochore.The Journal of cell biology · 2016Article
- Novel insights into mitotic chromosome condensation.F1000Research · 2016Review
- Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase.PloS one · 2016Article
- Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg.Journal of assisted reproduction and genetics · 2015Article
- The energy components of stacked chromatin layers explain the morphology, dimensions and mechanical properties of metaphase chromosomes.Journal of the Royal Society, Interface · 2014Article
- Centromeric heterochromatin: the primordial segregation machine.Annual review of genetics · 2014Review
- Pericentric chromatin loops function as a nonlinear spring in mitotic force balance.The Journal of cell biology · 2013Article
- Self-organization of domain structures by DNA-loop-extruding enzymes.Nucleic acids research · 2012Article
- Force probing of individual molecules inside the living cell is now a reality.Nature chemical biology · 2012Review
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Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Eukaryote cells dramatically reorganize their long chromosomal DNAs to facilitate their physical segregation during mitosis. The internal organization of folded mitotic chromosomes remains a basic mystery of cell biology; its understanding would likely shed light on how chromosomes are separated from one another as well as into chromosome structure between cell divisions. We report biophysical experiments on single mitotic chromosomes from human cells, where we combine micromanipulation, nano-Newton-scale force measurement and biochemical treatments to study chromosome connectivity and topology. Results are in accord with previous experiments on amphibian chromosomes and support the 'chromatin network' model of mitotic chromosome structure. Prospects for studies of chromosome-organizing proteins using siRNA expression knockdowns, as well as for differential studies of chromosomes with and without mutations associated with genetic diseases, are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.