ArticlePhysical biology2011
Single-cell bioelectrical impedance platform for monitoring cellular response to drug treatment.
Article in Physical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Code-multiplexed multi-frequency impedance cytometry with a unified deep-unfolding network.Microsystems & nanoengineering · 2026Article
- Phenotypic Characterization of 2D and 3D Prostate Cancer Cell Systems Using Electrical Impedance Spectroscopy.Biosensors · 2023Article
- Evaluation of Cancer Cell Lines by Four-Point Probe Technique, by Impedance Measurements in Various Frequencies.Biosensors · 2021Article
- Electrical Impedance Spectroscopy for Monitoring Chemoresistance of Cancer Cells.Micromachines · 2020Review
- Biosensor of Inflammation Biomarkers Based on Electrical Bioimpedance Analysis on Immobilized DNA Without Chemical Modification.Journal of electrical bioimpedance · 2020Article
- Bio-impedance measurement allows displaying the early stages of neutrophil extracellular traps.EXCLI journal · 2020Article
- A Multidisciplinary Approach Toward High Throughput Label-Free Cytotoxicity Monitoring of Superparamagnetic Iron Oxide Nanoparticles.Bioengineering (Basel, Switzerland) · 2019Article
- A microfluidic platform for drug screening in a 3D cancer microenvironment.Biosensors & bioelectronics · 2017Article
- Zinc oxide nanorod field effect transistor for long-time cellular force measurement.Scientific reports · 2017Article
- Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells.Scientific reports · 2015Article
- Nanostructured gold microelectrodes for SERS and EIS measurements by incorporating ZnO nanorod growth with electroplating.Scientific reports · 2015Article
- Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization.International journal of molecular sciences · 2015Review
- Real-time monitoring of immobilized single yeast cells through multifrequency electrical impedance spectroscopy.Analytical and bioanalytical chemistry · 2014Article
- Chip based single cell analysis for nanotoxicity assessment.The Analyst · 2014Review
- A new toolbox for assessing single cells.Annual review of chemical and biomolecular engineering · 2014Review
- Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform.International journal of nanomedicine · 2014Review
- Electric impedance microflow cytometry for characterization of cell disease states.Lab on a chip · 2013Article
- Design, fabrication and characterization of a low-impedance 3D electrode array system for neuro-electrophysiology.Sensors (Basel, Switzerland) · 2012Article
- Microfabricated electrochemical cell-based biosensors for analysis of living cells in vitro.Biosensors · 2012Review
- Effects of electrode surface modification with chlorotoxin on patterning single glioma cells.Physical chemistry chemical physics : PCCP · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The response of cells to a chemical or biological agent in terms of their impedance changes in real-time is a useful mechanism that can be utilized for a wide variety of biomedical and environmental applications. The use of a single-cell-based analytical platform could be an effective approach to acquiring more sensitive cell impedance measurements, particularly in applications where only diminutive changes in impedance are expected. Here, we report the development of an on-chip cell impedance biosensor with two types of electrodes that host individual cells and cell populations, respectively, to study its efficacy in detecting cellular response. Human glioblastoma (U87MG) cells were patterned on single- and multi-cell electrodes through ligand-mediated natural cell adhesion. We comparatively investigated how these cancer cells on both types of electrodes respond to an ion channel inhibitor, chlorotoxin (CTX), in terms of their shape alternations and impedance changes to exploit the fine detectability of the single-cell-based system. The detecting electrodes hosting single cells exhibited a significant reduction in the real impedance signal, while electrodes hosting confluent monolayer of cells showed little to no impedance change. When single-cell electrodes were treated with CTX of different doses, a dose-dependent impedance change was observed. This enables us to identify the effective dose needed for this particular treatment. Our study demonstrated that this single-cell impedance system may potentially serve as a useful analytical tool for biomedical applications such as environmental toxin detection and drug evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.