ArticlePhysical biology2011
Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology.
Article in Physical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- miR-18a-5p derived from mesenchymal stem cells-extracellular vesicles inhibits ovarian cancer cell proliferation, migration, invasion, and chemotherapy resistance.Journal of translational medicine · 2022Article
- Identification of potential markers for differentiating epithelial ovarian cancer from ovarian low malignant potential tumors through integrated bioinformatics analysis.Journal of ovarian research · 2021Article
- Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.Nature structural & molecular biology · 2020Article
- Single-cell morphology encodes metastatic potential.Science advances · 2020Article
- NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.Stem cell reports · 2017Article
- Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells.Molecular medicine reports · 2017Article
- Effect of taxol on the expression ofOncology letters · 2016Article
- Evolution of cellular morpho-phenotypes in cancer metastasis.Scientific reports · 2015Article
- Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.Cancer science · 2015Article
- Nac1 interacts with the POZ-domain transcription factor, Miz1.Bioscience reports · 2014Article
- Identification of the NAC1-regulated genes in ovarian cancer.The American journal of pathology · 2014Article
- Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair.Biomaterials · 2013Article
- Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Functional interplay between the cell cycle and cell phenotypes.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells.Cancer research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
NAC1, a BTB/POZ family member, has been suggested to participate in maintaining the stemness of embryonic stem cells and has been implicated in the pathogenesis of human cancer. In ovarian cancer, NAC1 upregulation is associated with disease aggressiveness and with the development of chemoresistance. Like other BTB/POZ proteins, NAC1 forms discrete nuclear bodies in non-dividing cells. To investigate the biological role of NAC1 nuclear bodies, we characterized the expression dynamics of NAC1 nuclear bodies during different phases of the cell cycle. Fluorescence recovery after photobleaching assays revealed that NAC1 was rapidly exchanged between the nucleoplasm and NAC1 nuclear bodies in interphase cells. The number of NAC1 bodies significantly increased and their size decreased in the S phase as compared to the G₀/G₁ and G₂ phases. NAC1 nuclear bodies disappeared and NAC1 became diffuse during mitosis. NAC1 nuclear bodies reappeared immediately after completion of mitosis. These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.