ArticleProceedings of the National Academy of Sciences of the United States of America2011
Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development.bioRxiv : the preprint server for biology · 2024Article
- Genome organization regulates nuclear pore complex formation and promotes differentiation duringGenes & development · 2024Article
- A feedback loop between heterochromatin and the nucleopore complex controls germ-cell-to-oocyte transition during Drosophila oogenesis.Developmental cell · 2023Article
- Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis.bioRxiv : the preprint server for biology · 2023Article
- RNA degradation is required for the germ-cell to maternal transition in Drosophila.Current biology : CB · 2021Article
- A comparative genomic approach using mouse and fruit fly data to discover genes involved in testis function in hymenopterans with a focus on Nasonia vitripennis.BMC ecology and evolution · 2021Article
- Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila.Nucleic acids research · 2020Article
- How do Wolbachia modify the Drosophila ovary? New evidences support the "titration-restitution" model for the mechanisms of Wolbachia-induced CI.BMC genomics · 2019Article
- Satellite DNA-containing gigantic introns in a unique gene expression program during Drosophila spermatogenesis.PLoS genetics · 2019Article
- Taming the giant within.PLoS genetics · 2019Article
- An RNA-binding protein Blanks plays important roles in defining small RNA and mRNA profiles inHeliyon · 2018Article
- DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1.Nature communications · 2017Article
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts.PLoS genetics · 2016Article
- Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis.Developmental biology · 2015Article
- Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.PloS one · 2014Article
- The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.Molecular and cellular biology · 2013Article
- Functional specialization of the small interfering RNA pathway in response to virus infection.PLoS pathogens · 2013Article
- LUMP is a putative double-stranded RNA binding protein required for male fertility in Drosophila melanogaster.PloS one · 2011Article
- Separating from the pack: Molecular mechanisms ofSpermatogenesisArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Small RNAs and a diverse array of protein partners control gene expression in eukaryotes through a variety of mechanisms. By combining siRNA affinity chromatography and mass spectrometry, we have identified the double-stranded RNA-binding domain protein Blanks to be an siRNA- and dsRNA-binding protein from Drosophila S2 cells. We find that Blanks is a nuclear factor that contributes to the efficiency of RNAi. Biochemical fractionation of a Blanks-containing complex shows that the Blanks complex is unlike previously described RNA-induced silencing complexes and associates with the DEAD-box helicase RM62, a protein previously implicated in RNA silencing. In flies, Blanks is highly expressed in testes tissues and is necessary for postmeiotic spermiogenesis, but loss of Blanks is not accompanied by detectable transposon derepression. Instead, genes related to innate immunity pathways are up-regulated in blanks mutant testes. These results reveal Blanks to be a unique component of a nuclear siRNA/dsRNA-binding complex that contributes to essential RNA silencing-related pathways in the male germ line.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.