Evidence map›Paper›PMID 21300848›Full record

ReviewThe Journal of cell biology2011

Circulating tumor cells: approaches to isolation and characterization.

Min Yu, Shannon Stott, Mehmet Toner, Shyamala Maheswaran, Daniel A Haber

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 517 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
517citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

517 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Effect of probioticWorld journal of gastroenterology · 2021
    Trial
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457 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Min YuHoward Hughes Medical Institute, Harvard Medical School, Charlestown, MA 02129, USA.
Shannon Stott
Mehmet Toner
Shyamala Maheswaran
Daniel A Haber

Funding

Bio-MicroElectroMechanical Systems Resource CenterP41EB002503 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET · 2004 to 2018
$17.4M
Howard Hughes Medical InstituteNIBIB NIH HHS P41 EB002503
6 · The paper itself

Abstract

Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with blood components and are thus rare, making their isolation and characterization a major technological challenge. CTCs hold the key to understanding the biology of metastasis and provide a biomarker to noninvasively measure the evolution of tumor genotypes during treatment and disease progression. Improvements in technologies to yield purer CTC populations amenable to better cellular and molecular characterization will enable a broad range of clinical applications, including early detection of disease and the discovery of biomarkers to predict treatment responses and disease progression.

Indexed as

Neoplastic Cells, CirculatingAnimalsAntigens, SurfaceBiomarkersCell SeparationDisease ProgressionHumansNeoplasmsAntigens, SurfaceBiomarkers

Identifiers

PMID21300848
PMCPMC3101098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.