ArticleMolecular and cellular biology2011
Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.Molecular cell · 2022Article
- Unravelling the biological secrets of microchimerism by single-cell analysis.Briefings in functional genomics · 2018Article
- Downregulation of p53 drives autophagy during human trophoblast differentiation.Cellular and molecular life sciences : CMLS · 2018Article
- Capturing and Interconverting Embryonic Cell Fates in a Dish.Current topics in developmental biology · 2018Review
- The plasticity of germ cell cancers and its dependence on the cellular microenvironment.Journal of cellular and molecular medicine · 2017Review
- Transcriptional Regulation of the First Cell Fate Decision.Journal of developmental biology & regenerative medicine · 2017Article
- Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells.Stem cell research & therapy · 2016Article
- Epigenesis and plasticity of mouse trophoblast stem cells.Cellular and molecular life sciences : CMLS · 2016Review
- Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators.Scientific reports · 2016Article
- Cdx2 efficiently induces trophoblast stem-like cells in naïve, but not primed, pluripotent stem cells.Stem cells and development · 2015Article
- Deficiency of genomic reprogramming in trophoblast stem cells following nuclear transfer.Cellular reprogramming · 2015Article
- Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.Nature communications · 2014Article
- Comparison of reprogramming genes in induced pluripotent stem cells and nuclear transfer cloned embryos.Stem cell reviews and reports · 2014Article
- Derivation and maintenance of murine trophoblast stem cells under defined conditions.Stem cell reports · 2014Article
- Transcriptional reprogramming and chromatin remodeling accompanies Oct4 and Nanog silencing in mouse trophoblast lineage.Stem cells and development · 2014Article
- Solving the "X" in embryos and stem cells.Stem cells and development · 2012Review
- X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells.Human genetics · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, the first cell fate decision is initialized by cell polarization at the 8- to 16-cell stage of the preimplantation embryo. At this stage, outside cells adopt a trophectoderm (TE) fate, whereas the inside cell population gives rise to the inner cell mass (ICM). Prior to implantation, transcriptional interaction networks and epigenetic modifications divide the extraembryonic and embryonic fate irrevocably. Here, we report that extraembryonic trophoblast stem cell (TSC) lines are converted to induced pluripotent stem cells (TSC-iPSCs) by overexpressing Oct4, Sox2, Klf4, and cMyc. Methylation studies and gene array analyses indicated that TSC-iPSCs had adopted a pluripotent potential. The rate of conversion was lower than those of somatic reprogramming experiments, probably due to the unique genetic network controlling extraembryonic lineage fixation. Both in vitro and in vivo, TSC-iPSCs differentiated into tissues representing all three embryonic germ layers, indicating that somatic cell fate could be induced. Finally, TSC-iPSCs chimerized the embryo proper and contributed to the germ line of mice, indicating that these cells had acquired full somatic differentiation potential. These results lead to a better understanding of the molecular processes that govern the first lineage decision in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.