ArticleInfection and immunity2011
Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- Impact of altered heme oxygenase-1 in caring for preterm neonates: navigating the unknown.Pediatric research · 2026Review
- A developmentally informed narrative review of Toll-like receptors in adult and pediatric acute respiratory distress syndrome.Annals of translational medicine · 2026Review
- The immune system of preterm infants: an overview.Frontiers in immunology · 2026Review
- Antibody dependent complement activation is critical for boosting opsonophagocytosis of Staphylococcus epidermidis in an extremely preterm human whole blood model.Scientific reports · 2025Article
- Early gut microbiota intervention in premature infants: Application perspectives.Journal of advanced research · 2023Review
- TLR Responses in Preterm and Term Infant Cord Blood Mononuclear Cells.Pathogens (Basel, Switzerland) · 2023Article
- The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study.Microorganisms · 2023Article
- The impact of early life experiences and gut microbiota on neurobehavioral development among preterm infants: A longitudinal cohort study.medRxiv : the preprint server for health sciences · 2023Article
- Dysregulated monocyte-derived macrophage response to Group BFrontiers in immunology · 2023Article
- Group B streptococci infection model shows decreased regulatory capacity of cord blood cells.Pediatric research · 2022Article
- Reelin cells and sex-dependent synaptopathology in autism following postnatal immune activation.British journal of pharmacology · 2022Article
- Catheter-related bloodstream infections in infants hospitalized in neonatal intensive care units: a single center study.Scientific reports · 2022Article
- Association of immune cell recruitment and BPD development.Molecular and cellular pediatrics · 2022Review
- Bacterial and Host Determinants of Group B Streptococcal Infection of the Neonate and Infant.Frontiers in microbiology · 2022Review
- Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury.International journal of molecular sciences · 2021Review
- Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum.Frontiers in immunology · 2021Article
- Whole blood transcriptional responses of very preterm infants during late-onset sepsis.PloS one · 2020Article
- [Group B streptococcus colonization in pregnant women and group B streptococcus infection in their preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- A Preterm Rat Model for Immunonutritional Studies.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group B streptococcus (GBS) is an important cause of early- and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility and worse outcomes, but their immunological responses to GBS are poorly defined. We compared mononuclear cell and whole-blood cytokine responses to heat-killed GBS (HKGBS) of preterm infants (gestational age [GA], 26 to 33 weeks), term infants, and healthy adults. We investigated the kinetics and cell source of induced cytokines and quantified HKGBS phagocytosis. HKGBS-induced tumor necrosis factor (TNF) and interleukin 6 (IL-6) secretion was significantly impaired in preterm infants compared to that in term infants and adults. These cytokines were predominantly monocytic in origin, and production was intrinsically linked to HKGBS phagocytosis. Very preterm infants (GA, <30 weeks) had fewer cytokine-producing monocytes, but nonopsonic phagocytosis ability was comparable to that for term infants and adults. Exogenous complement supplementation increased phagocytosis in all groups, as well as the proportion of preterm monocytes producing IL-6, but for very preterm infants, responses were still deficient. Similar defective preterm monocyte responses were observed in fresh whole cord blood stimulated with live GBS. Lymphocyte-associated cytokines were significantly deficient for both preterm and term infants compared to levels for adults. These findings indicate that a subset of preterm monocytes do not respond to GBS, a defect compounded by generalized weaker lymphocyte responses in newborns. Together these deficient responses may increase the susceptibility of preterm infants to GBS infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.