ArticlePediatrics2011
Prenatal factors for childhood blood pressure mediated by intrauterine and/or childhood growth?
Article in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis.Current hypertension reports · 2024Pooled it
- Maternal smoking in pregnancy and blood pressure during childhood and adolescence: a meta-analysis.European journal of pediatrics · 2023Pooled it
- Calcium supplementation during pregnancy and long-term offspring outcome: a systematic literature review and meta-analysis.Annals of the New York Academy of Sciences · 2022Pooled it
- Effect of passive exposure to cigarette smoke on blood pressure in children and adolescents: a meta-analysis of epidemiologic studies.BMC pediatrics · 2019Pooled it
- Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review.Maternal & child nutrition · 2018Pooled it
- Effect of maternal smoking during pregnancy on child blood pressure in a European cohort.Scientific reports · 2022Trial
- Pre-pregnancy parental BMI and offspring blood pressure in infancy.European journal of preventive cardiology · 2019Trial
- Associations of social and economic and pregnancy exposures with blood pressure in UK White British and Pakistani children age 4/5.Scientific reports · 2018Trial
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- Early Determinants of Childhood Blood Pressure at the Age of 6 Years: The GECKO Drenthe and ABCD Study Birth Cohorts.Journal of the American Heart Association · 2020Article
- Early-Life Predictors of Systolic Blood Pressure Trajectories From Infancy to Adolescence: Findings From Project Viva.American journal of epidemiology · 2019Article
- Association of accelerated body mass index gain with repeated measures of blood pressure in early childhood.International journal of obesity (2005) · 2019Article
- Hypertensive disorders during pregnancy and elevated blood pressure in the offspring: A systematical review and meta-analysis protocol.Medicine · 2019Article
- Article
- Impact of Metabolic Hormones Secreted in Human Breast Milk on Nutritional Programming in Childhood Obesity.Journal of mammary gland biology and neoplasia · 2017Review
- Mother's Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort.Scientific reports · 2017Article
- Racial Disparities in Blood Pressure Trajectories of Preterm Children: The Role of Family and Neighborhood Socioeconomic Status.American journal of epidemiology · 2017Article
- Placental microRNA Expression Is Not Altered by Maternal Obesity and Fetal Overgrowth.AJP reports · 2016Article
- Fetal growth restriction and cardiovascular outcome in early human infancy: a prospective longitudinal study.Heart and vessels · 2016Article
- The Effect of an Obesogenic Maternal Environment on Expression of Fetal Umbilical Cord Blood miRNA.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveSome prenatal factors may program an offspring's blood pressure, but existing evidence is inconclusive and mechanisms remain unclear. We examined the mediating roles of intrauterine and childhood growth in the associations between childhood systolic blood pressure (SBP) and 5 potentially modifiable prenatal factors: maternal smoking during pregnancy; prepregnancy BMI; pregnancy weight gain; chronic hypertension; and preeclampsia-eclampsia.
methodsThe sample contained 30 461 mother-child pairs in the Collaborative Perinatal Project. Prenatal data were extracted from obstetric forms, and children's SBP was measured at 7 years of age. Potential mediation by intrauterine growth restriction (IUGR) and childhood growth was examined by the causal step method.
resultsHeavy maternal smoking during pregnancy was significantly associated with higher offspring SBP (adjusted mean difference versus nonsmoking: 0.73 mm Hg [95% confidence interval (CI): 0.32-1.14]), which attenuated to null (0.13 [95% CI: -0.27-0.54]) after adjustment for changes in BMI from birth to 7 years of age. Prepregnancy overweight-obesity was significantly associated with higher offspring SBP (versus normal weight: 0.89 mm Hg [95% CI: 0.52-1.26]), which also attenuated to null (-0.04 mm Hg [95% CI: -0.40-0.31]) after adjustment for childhood BMI trajectory. Adjustment for BMI trajectory augmented the association between maternal pregnancy weight gain and offspring SBP. Adjustment for childhood weight trajectory similarly changed these associations. However, all these associations were independent of IUGR.
conclusionsChildhood BMI and weight trajectory, but not IUGR, may largely mediate the associations of maternal smoking during pregnancy and prepregnancy BMI with an offspring's SBP.
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