ArticleNucleic acids research2011
Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Heterodisomy in theFrontiers in endocrinology · 2024Article
- Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines.Clinical epigenetics · 2022Article
- Along the Bos taurus genome, uncover candidate imprinting control regions.BMC genomics · 2022Article
- The SUV4-20H Histone Methyltransferases in Health and Disease.International journal of molecular sciences · 2022Review
- Crosstalk Between mRNA 3'-End Processing and Epigenetics.Frontiers in genetics · 2021Review
- Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.Nature communications · 2020Article
- A comprehensive overview of genomic imprinting in breast and its deregulation in cancer.Nature communications · 2018Review
- Pollen-specific activation of Arabidopsis retrogenes is associated with global transcriptional reprogramming.The Plant cell · 2014Article
- Transcriptome-wide investigation of genomic imprinting in chicken.Nucleic acids research · 2014Article
- Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.BMC cancer · 2013Article
- DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation.BMC genomics · 2013Article
- Importance of the matriline for genomic imprinting, brain development and behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Article
- Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus.Nucleic acids research · 2012Article
- Sequence and expression analysis of gaps in human chromosome 20.Nucleic acids research · 2012Article
- Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance.Genome research · 2012Article
- The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.ILAR journal · 2012Review
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13 authors.
Funding
Abstract
Imprinted retrotransposed genes share a common genomic organization including a promoter-associated differentially methylated region (DMR) and a position within the intron of a multi-exonic 'host' gene. In the mouse, at least one transcript of the host gene is also subject to genomic imprinting. Human retrogene orthologues are imprinted and we reveal that human host genes are not imprinted. This coincides with genomic rearrangements that occurred during primate evolution, which increase the separation between the retrogene DMRs and the host genes. To address the mechanisms governing imprinted retrogene expression, histone modifications were assayed at the DMRs. For the mouse retrogenes, the active mark H3K4me2 was associated with the unmethylated paternal allele, while the methylated maternal allele was enriched in repressive marks including H3K9me3 and H4K20me3. Two human retrogenes showed monoallelic enrichment of active, but not of repressive marks suggesting a partial uncoupling of the relationship between DNA methylation and repressive histone methylation, possibly due to the smaller size and lower CpG density of these DMRs. Finally, we show that the genes immediately flanking the host genes in mouse and human are biallelically expressed in a range of tissues, suggesting that these loci are distinct from large imprinted clusters.
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