ReviewThe Journal of steroid biochemistry and molecular biology2011
Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathways.
Review in The Journal of steroid biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Molecular Mechanism of Sterilization by Quinestrol, a Rodent Sterility Control Agent.Integrative zoology · 2026Article
- Analysis of bisphenol A-modulated expression of hypothalamic thyroid, estrogen, and peroxisome proliferator-activated receptors and concurrent mitochondrial dynamics following short-term exposure in mice.Current research in toxicology · 2025Article
- Xenoestrogen concentration in women with endometriosis or leiomyomas: A case-control study.PloS one · 2024Article
- Article
- BPA interferes with granulosa cell development and oocyte meiosis in mouse preantral follicles.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- UV-Cured Green Polymers for Biosensorics: Correlation of Operational Parameters of Highly Sensitive Biosensors with Nano-Volumes and Adsorption Properties.Materials (Basel, Switzerland) · 2022Article
- Are BPA Substitutes as Obesogenic as BPA?International journal of molecular sciences · 2022Review
- [Rapid determination of bisphenols in surface water by modified QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2022Article
- Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System.International journal of endocrinology · 2020Review
- Hypoxia Limits the Growth of Bovine Follicles in Vitro by Inhibiting Estrogen Receptor α.Animals : an open access journal from MDPI · 2019Article
- Endocrine disruption through membrane estrogen receptors and novel pathways leading to rapid toxicological and epigenetic effects.The Journal of steroid biochemistry and molecular biology · 2019Review
- Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice.American journal of physiology. Renal physiology · 2018Article
- Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Nutrichemistry, a means of preventing and healing chronic diseases.Electronic physician · 2017Review
- Estrogens regulate life and death in mitochondria.Journal of bioenergetics and biomembranes · 2017Review
- Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes.Scientific reports · 2015Article
- Direct estradiol and diethylstilbestrol actions on early- versus late-stage prostate cancer cells.The Prostate · 2014Article
- Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver.Environmental and molecular mutagenesis · 2014Article
- Multi-well plate immunoassays for measuring signaling protein activations/deactivations and membrane vs. intracellular receptor levels.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.Reproductive toxicology (Elmsford, N.Y.) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When inappropriate (non-physiologic) estrogens affect organisms at critical times of estrogen sensitivity, disruption of normal endocrine functions can result. Non-physiologic estrogen mimetics (environmental, dietary, and pharmaceutical) can signal rapidly and potently via the membrane versions of estrogen receptors, as can physiologic estrogens. Both physiologic and non-physiologic estrogens activate multiple signaling pathways, leading to altered cellular functions (e.g. peptide release, cell proliferation or death, transport). Xenoestrogens' mimicry of physiologic estrogens is imperfect. When superimposed, xenoestrogens can alter endogenous estrogens' signaling and thereby disrupt normal signaling pathways, leading to malfunctions in many tissue types. Though these xenoestrogen actions occur rapidly via nongenomic signaling pathways, they can be sustained with continuing ligand stimulation, combinations of ligands, and signaling that perpetuates downstream, eventually also impinging on genomic regulation by controlling the activation state of transcription factors. Because via these pathways estrogens and xenoestrogens cause nonmonotonic stimulation patterns, they must be carefully tested for activity and toxicity over wide dose ranges. Nongenomic actions of xenoestrogens in combination with each other, and with physiologic estrogens, are still largely unexplored from these mechanistic perspectives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.