Evidence map›Paper›PMID 21298800›Full record

ReviewBiotechnology journal2011

Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing.

Umut Atakan Gurkan, Sangjun Moon, Hikmet Geckil, Feng Xu, Shuqi Wang, Tian Jian Lu, Utkan Demirci

Open access · bronzeAbstract readReview
In one paragraph

Review in Biotechnology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 101 citations in OpenAlex.

  1. Review
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  9. Microfluidic Based Optical Microscopes on Chip.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Umut Atakan GurkanDemirci Bio-Acoustic MEMS in Medicine (BAMM) Labs at the HST-BWH Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. udemirci@rics.bwh.harvard.edu
Sangjun Moon
Hikmet Geckil
Feng Xu
Shuqi Wang
Tian Jian Lu
Utkan Demirci
Harvard University · USBrigham and Women's Hospital · USMassachusetts Institute of Technology · USXi'an Jiaotong University · CN

Funding

Point-of-Care Rapid Blood Testing Using Microfluidic DevicesR01AI081534 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2009 to 2013
$2.1M
Antibody-based cell purification at resource limited setting for HIVR21AI087107 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2010 to 2011
$488k
Droplet Based Microfluidic Chip for CryopreservationR21EB007707 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2008 to 2009
$478k
NIAID NIH HHS R01 AI081534NIAID NIH HHS R01AI081534NIAID NIH HHS R21 AI087107NIAID NIH HHS R21AI087107NIBIB NIH HHS R21 EB007707
6 · The paper itself

Abstract

Low-cost, robust, and user-friendly diagnostic capabilities at the point-of-care (POC) are critical for treating infectious diseases and preventing their spread in developing countries. Recent advances in micro- and nanoscale technologies have enabled the merger of optical and fluidic technologies (optofluidics) paving the way for cost-effective lensless imaging and diagnosis for POC testing in resource-limited settings. Applications of the emerging lensless imaging technologies include detecting and counting cells of interest, which allows rapid and affordable diagnostic decisions. This review presents the advances in lensless imaging and diagnostic systems, and their potential clinical applications in developing countries. The emerging technologies are reviewed from a POC perspective considering cost effectiveness, portability, sensitivity, throughput and ease of use for resource-limited settings.

Indexed as

Diagnostic ImagingHumansMicrofluidic Analytical TechniquesPoint-of-Care Systems

Identifiers

PMID21298800
PMCPMC3066565
OpenAlexW2059418999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.