ReviewClinical cardiology2011
Association of warfarin use with valvular and vascular calcification: a review.
Review in Clinical cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Analysis of the clinical characteristics of warfarin-associated purple toe syndrome.Clinical and experimental medicine · 2026Article
- Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study.International journal of women's health · 2025Article
- Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease.International journal of molecular sciences · 2022Review
- Review
- Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression.Oxidative medicine and cellular longevity · 2020Article
- Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions.Current developments in nutrition · 2019Review
- Missense mutation of VKORC1 leads to medial arterial calcification in rats.Scientific reports · 2018Article
- Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study.Journal of the American Heart Association · 2018Observational
- Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.BMC nephrology · 2014Observational
- Two cases of warfarin-induced tracheobronchial calcification after Fontan surgery.Pediatric cardiology · 2014Article
- Are there ways to attenuate arterial calcification and improve cardiovascular outcomes in chronic kidney disease?World journal of cardiology · 2014Review
- Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Vitamin K status in chronic kidney disease: a report of a study and a mini-review.International urology and nephrology · 2013Review
- Mineralization/anti-mineralization networks in the skin and vascular connective tissues.The American journal of pathology · 2013Review
- Aortic valve reconstruction with autologous pericardium for dialysis patients.Interactive cardiovascular and thoracic surgery · 2013Article
- Fibroblast involvement in soft connective tissue calcification.Frontiers in genetics · 2013Article
- Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Genetic pathways of vascular calcification.Trends in cardiovascular medicine · 2012Review
- Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Matrix Gla protein deficiency causes arteriovenous malformations in mice.The Journal of clinical investigation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin K is required for the activity of various biologically active proteins in our body. Apart from clotting factors, vitamin K-dependent proteins include regulatory proteins like protein C, protein S, protein Z, osteocalcin, growth arrest-specific gene 6 protein, and matrix Gla protein. Glutamic acid residues in matrix Gla protein are γ-carboxylated by vitamin K-dependent γ-carboxylase, which enables it to inhibit calcification. Warfarin, being a vitamin K antagonist, inhibits this process, and has been associated with calcification in various animal and human studies. Though no specific guidelines are currently available to prevent or treat this less-recognized side effect, discontinuing warfarin and using an alternative anticoagulant seems to be a reasonable option. Newer anticoagulants such as dabigatran and rivaroxaban offer promise as future therapeutic options in such cases. Drugs including statins, alendronate, osteoprotegerin, and vitamin K are currently under study as therapies to prevent or treat warfarin-associated calcification. Copyright © 2011 Wiley Periodicals, Inc. The authors have no funding, financial relationships, or conflicts of interest to disclose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.