ArticleDevelopmental psychobiology2011
Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants.
Article in Developmental psychobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 134 citations in OpenAlex.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
- Betamethasone latency period and neonatal hypoglycemia in term infants.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025Article
- Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications.Frontiers in endocrinology · 2025Review
- Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.Developmental psychology · 2024Review
- A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk.Frontiers in endocrinology · 2023Review
- Exposure to antenatal corticosteroids and infant cortisol regulation.Psychoneuroendocrinology · 2023Article
- Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits.Advances in drug and alcohol research · 2023Review
- Infection and higher cortisol during pregnancy and risk for depressive symptoms in adolescent offspring.Psychoneuroendocrinology · 2022Article
- Metabolic Consequences of Glucocorticoid Exposure before Birth.Nutrients · 2022Review
- Ambulatory Blood Pressure Monitoring in Children and Adults Prenatally Exposed to Dexamethasone Treatment.The Journal of clinical endocrinology and metabolism · 2022Article
- What is known about neuroplacentology in fetal growth restriction and in preterm infants: A narrative review of literature.Frontiers in endocrinology · 2022Review
- Maternal prenatal cortisol programs the infant hypothalamic-pituitary-adrenal axis.Psychoneuroendocrinology · 2021Article
- Birth signalling hormones and the developmental consequences of caesarean delivery.Journal of neuroendocrinology · 2021Review
- Maternal cortisol during pregnancy and offspring schizophrenia: Influence of fetal sex and timing of exposure.Schizophrenia research · 2019Article
- Placental programming of neuropsychiatric disease.Pediatric research · 2019Review
- Prenatal Risk for ASD: Fetal Cortisol Exposure Predicts Child Autism-Spectrum Disorder Symptoms.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
- Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors.Biological psychiatry · 2019Article
- Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood - Depression (PRAM-D) Study.Psychoneuroendocrinology · 2018Article
- Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation.Journal of molecular endocrinology · 2018Review
- Long-term impacts of prenatal synthetic glucocorticoids exposure on functional brain correlates of cognitive monitoring in adolescence.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to determine the consequences for HPA axis functioning among healthy full-term newborns of prenatal treatment with the synthetic glucocorticoid (GC), betamethasone, which is the routine treatment for threatened preterm delivery. Ninety full-term infants were recruited into two study groups (30 betamethasone treated; 60 comparison group matched for GA at birth and sex). The cortisol and behavioral response to the painful stress of a heel-stick blood draw was assessed 24 hr after birth. Full-term infants exposed to prenatal betamethasone displayed a larger cortisol response to the heel-stick procedure, despite no differences in baseline levels. Further, within the recommended window of betamethasone administration (24-34 gestational weeks), infants exposed to betamethasone earlier in gestation displayed the largest cortisol response to the heel-stick. These data add to accumulating evidence that prenatal exposure to elevated GCs programs the development of the HPA axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.