ArticleCurrent neurology and neuroscience reports2011
The pathophysiologic basis of secondary narcolepsy and hypersomnia.
Article in Current neurology and neuroscience reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Pitolisant-associated mania - a case report.BMC neurology · 2026Article
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- A comparative study of hypothalamic involvement in patients with myelin oligodendrocyte glycoprotein antibody-associated disease, neuromyelitis optica spectrum disorder, and multiple sclerosis.European journal of neurology · 2024Article
- Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1.Internal medicine (Tokyo, Japan) · 2022Article
- Case Report: Dysfunction of the Paraventricular Hypothalamic Nucleus Area Induces Hypersomnia in Patients.Frontiers in neuroscience · 2022Article
- Suspected acquired narcolepsy in 8 dogs.Journal of veterinary internal medicine · 2021Article
- Neuromyelitis Optica Spectrum Disorders (NMOSD) and Connective Tissue Disease (CTD): an Update for the Rheumatologist.Current rheumatology reports · 2021Review
- Sudden onset of sleep caused by hypothalamic infarction: a case report.BMC neurology · 2019Article
- Update on narcolepsy.Journal of neurology · 2019Review
- The neurobiological basis of narcolepsy.Nature reviews. Neuroscience · 2019Review
- Article
- Cerebrospinal-fluid orexin levels and daytime somnolence in frontotemporal dementia.Journal of neurology · 2014Article
- Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle.Frontiers in neurology · 2014Review
- Reduced orexin-A levels in frontotemporal dementia: possible association with sleep disturbance.American journal of Alzheimer's disease and other dementias · 2013Article
- Classification of sleep disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Narcolepsy in the pediatric population.Current neurology and neuroscience reports · 2012Article
- Symptomatic Narcolepsy as a Presenting Feature of Neuromyelitis Optica.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symptoms of narcolepsy can occur during the course of other neurologic conditions (ie, symptomatic narcolepsy). Inherited disorders, tumors, and head trauma were the three most frequent causes for symptomatic narcolepsy. Other causes include multiple sclerosis (MS), vascular disorders, and encephalitis. Cerebrospinal fluid hypocretin-1 measures were carried out in some recent cases with symptomatic narcolepsy, and moderate decreases in hypocretin levels were seen in a large majority of these cases. Excessive daytime sleepiness (EDS) in these symptomatic cases was sometimes reversible with an improvement of the causative neurologic disorder and with an improvement of the hypocretin (orexin) status. Recently, we found that several symptomatic narcoleptic cases with MS show unique bilateral symmetric hypothalamic lesions associated with significant hypocretin ligand deficiency. In addition, these patients often share the clinical characteristics of neuromyelitis optica (NMO) and the detection of NMO-IgG (or anti-aquaporin-4 [AQP4] antibodies), suggesting a new clinical entity. Further studies of the involvement of the hypocretin system in symptomatic narcolepsy and EDS are helpful to understand the pathophysiologic mechanisms for occurrence of EDS and cataplexy.
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Registered trials
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