Evidence map›Paper›PMID 21298367›Full record

ArticleMedical oncology (Northwood, London, England)2012

Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia.

N Colovic, D Tomin, A Vidovic, N Tosic, H D Atkinson, Milica D Colovic

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

N ColovicInstitute of Hematology, Clinical Center for Serbia, Koste Todorovića 2, 11000 Belgrade, Serbia. natasacolovic73@gmail.com
D Tomin
A Vidovic
N Tosic
H D Atkinson
Milica D Colovic
Grade Medical (Czechia) · CZCentar za Promociju Nauke · RSInstitute of Molecular Genetics and Genetic EngineeringMiddlesex University · GBUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous system (CNS) involvement in acute promyelocytic leukemia (APL) is rare and tends to be seen mostly following treatment with all-trans retinoic acid (ATRA), due to prolonged patient survival and poor penetration of the drug in the CNS. At least 10% of extramedullary relapses in APL involve the CNS, and associated factors include an increased age, the BCR isoform, the development of differentiation syndrome, a high white cell count at presentation and hemorrhage into the CNS during induction therapy. We present the case of a patient with high-risk APL, CD56+, CD2+ in whom a CNS relapse was diagnosed through the presence of a PML/RARα rearrangement on PCR of the cerebrospinal fluid (CSF).

Indexed as

AdultAntineoplastic AgentsCD56 AntigenCentral Nervous System NeoplasmsFatal Outcomefms-Like Tyrosine Kinase 3HumansLeukemia, Promyelocytic, AcuteMaleNeoplasm Recurrence, LocalOncogene Proteins, FusionPolymerase Chain ReactionTretinoinAntineoplastic AgentsCD56 AntigenFLT3 protein, humanfms-Like Tyrosine Kinase 3Oncogene Proteins, Fusionpromyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinTretinoin

Identifiers

PMID21298367
OpenAlexW1993827858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.