ArticlePloS one2011
Respiratory infections by HMPV and RSV are clinically indistinguishable but induce different host response in aged individuals.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Human Metapneumovirus (HMPV): Advances in Diagnosis, Molecular Epidemiology, and Clinical Impact of an Underrecognized Respiratory Virus.Diagnostics (Basel, Switzerland) · 2026Review
- Avian Metapneumovirus: Virology, Epidemiology, and Insights from a Comparative Analysis with Human Metapneumovirus-A Review.Biomolecules · 2026Review
- Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19.Cell and tissue banking · 2020Review
- Non-Coding RNAs and Their Role in Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (hMPV) Infections.Viruses · 2020Review
- Oncotype DX Breast Cancer recurrence score resists inter-assay reproducibility with RTScientific reports · 2019Article
- Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- Time series non-Gaussian Bayesian bivariate model applied to data on HMPV and RSV: a case of Dadaab in Kenya.BMC public health · 2019Article
- Innate immune responses in the ageing lung.Clinical and experimental immunology · 2017Review
- Bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in Dhaka city.PloS one · 2017Article
- Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model.Pathogens (Basel, Switzerland) · 2015Review
- Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells.Journal of virology · 2015Article
- Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells.Mediators of inflammation · 2015Article
- Human metapneumovirus: review of an important respiratory pathogen.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2014Review
- Seasonality and prevalence of respiratory pathogens detected by multiplex PCR at a tertiary care medical center.Archives of virology · 2014Article
- Human metapneumovirus in adults.Viruses · 2013Review
- Article
- In vitro anti-HMPV activity of meroditerpenoids from marine alga Stypopodium zonale (Dictyotales).Molecules (Basel, Switzerland) · 2011Article
- Human Metapneumovirus: lessons learned over the first decade.Clinical microbiology reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman metapneumovirus and respiratory syncytial virus can cause severe respiratory diseases, especially in infants, young children, and the elderly. So far it remains unclear why infections in the elderly become life threatening despite the presence of neutralizing antibodies in the serum, and to which extent double infections worsen the clinical course.
methodsYoung and aged BALB/c-mice were infected with RSV or/and HMPV. Appearance of the mice was observed during course of infection. On day 5 p.i. animals were dispatched by cervical dislocation and levels of TNF-α and NF-κB were determined.
resultsThe observation of activity, weight and appearance of the different mice showed no differences among the tested groups. Despite this, the immunologic response depends on the animals' age and the virus they were infected with. In young animals, NF-κB levels were elevated if infected with HMPV and HMPV/RSV but remained low in RSV infections, whereas in aged animals the opposite was observed: solely RSV-infected animals showed elevated levels of NF-κB. TNF-α was slightly elevated in HMPV-infected young and old animals, but only in young animals this elevation was significant.
conclusionsContrary to other studies, no weight loss or change in activity despite productive lung infection with the different viruses were observed. This may be due to the weaker anaesthesia or the lesser volume of virus solution used, leading to less stress in the animals. The observed differences in TNF-α and NF-κB elevation lead to the assumption that young and old individuals have different mechanisms to react against the viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.