ArticlePloS one2011
DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder?
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.Molecular psychiatry · 2018Article
- Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum.Frontiers in molecular neuroscience · 2018Article
- Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.The Journal of clinical investigation · 2017Article
- DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.Journal of studies on alcohol and drugs · 2016Article
- DISC1 genetics, biology and psychiatric illness.Frontiers in biology · 2013Article
- Born to yawn? Understanding yawning as a warning of the rise in cortisol levels: randomized trial.Interactive journal of medical research · 2012Article
- Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?Molecular psychiatry · 2012Review
- An automated bayesian framework for integrative gene expression analysis and predictive medicine.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2012Article
- Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.PloS one · 2012Article
- DISC1 at 10: connecting psychiatric genetics and neuroscience.Trends in molecular medicine · 2011Review
- Linking neurodevelopmental and synaptic theories of mental illness through DISC1.Nature reviews. Neuroscience · 2011Review
- DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness.ACS chemical neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We re-annotated the interacting partners of the neuronal scaffold protein DISC1 using a knowledge-based approach that incorporated recent protein interaction data and published literature to. This revealed two highly connected networks. These networks feature cellular function and maintenance, and cell signaling. Of potentially greatest interest was the novel finding of a high degree of connectivity between the DISC1 scaffold protein, linked to psychiatric illness, and huntingtin, the protein which is mutated in Huntington's disease. The potential link between DISC1, huntingtin and their interacting partners may open new areas of research into the effects of pathway dysregulation in severe neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.