ArticlePloS one2011
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic Factors of Teeth Impaction: Polymorphic and Haplotype Variants ofInternational journal of molecular sciences · 2023Article
- How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data.Genetics and molecular biology · 2018Article
- Differing evolutionary histories of the ACTN3*R577X polymorphism among the major human geographic groups.PloS one · 2015Article
- A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism.PloS one · 2015Article
- PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China.Journal of applied oral science : revista FOB · 2013Article
- Is the human species still evolving? To where?Genetics and molecular biology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5'and 3'flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works.
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