Evidence map›Paper›PMID 21298013›Full record

ArticlePloS one2011

Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Welkin H Pope, Deborah Jacobs-Sera, Daniel A Russell, Craig L Peebles, Zein Al-Atrache, Turi A Alcoser, Lisa M Alexander, Matthew B Alfano, Samantha T Alford, Nichols E Amy and 182 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Characterization of four cluster A1Microbiology resource announcements · 2025
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  10. Review
  11. Article
  12. Complete Genome Sequences ofmicroPublication biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Complete genome sequences of cluster F1 and cluster B1Microbiology resource announcements · 2024
    Article
  17. Article
  18. Isolation and identification of a novel phage targeting clinical multidrug-resistantFrontiers in cellular and infection microbiology · 2024
    Article
  19. Fly-CURE, a multi-institutional CURE usingJournal of microbiology & biology education · 2023
    Article
  20. Complete genome sequences of cluster G1 and cluster K4Microbiology resource announcements · 2023
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

192 authors at 16 institutions in 1 country.

Welkin H PopeDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Deborah Jacobs-Sera
Daniel A Russell
Craig L Peebles
Zein Al-Atrache
Turi A Alcoser
Lisa M Alexander
Matthew B Alfano
Samantha T Alford
Nichols E Amy
Marie D Anderson
Alexander G Anderson
Andrew A S Ang
Manuel Ares
Amanda J Barber
Lucia P Barker
Jonathan M Barrett
William D Barshop
Cynthia M Bauerle
Ian M Bayles
Katherine L Belfield
Aaron A Best
Agustin Borjon
Charles A Bowman
Christine A Boyer
Kevin W Bradley
Victoria A Bradley
Lauren N Broadway
Keshav Budwal
Kayla N Busby
Ian W Campbell
Anne M Campbell
Alyssa Carey
Steven M Caruso
Rebekah D Chew
Chelsea L Cockburn
Lianne B Cohen
Jeffrey M Corajod
Steven G Cresawn
Kimberly R Davis
Lisa Deng
Dee R Denver
Breyon R Dixon
Sahrish Ekram
Sarah C R Elgin
Angela E Engelsen
Belle E V English
Marcella L Erb
Crystal Estrada
Laura Z Filliger
Ann M Findley
Lauren Forbes
Mark H Forsyth
Tyler M Fox
Melissa J Fritz
Roberto Garcia
Zindzi D George
Anne E Georges
Christopher R Gissendanner
Shannon Goff
Rebecca Goldstein
Kobie C Gordon
Russell D Green
Stephanie L Guerra
Krysta R Guiney-Olsen
Bridget G Guiza
Leila Haghighat
Garrett V Hagopian
Catherine J Harmon
Jeremy S Harmson
Grant A Hartzog
Samuel E Harvey
Siping He
Kevin J He
Kaitlin E Healy
Ellen R Higinbotham
Erin N Hildebrandt
Jason H Ho
Gina M Hogan
Victoria G Hohenstein
Nathan A Holz
Vincent J Huang
Ericka L Hufford
Peter M Hynes
Arrykka S Jackson
Erica C Jansen
Jonathan Jarvik
Paul G Jasinto
Tuajuanda C Jordan
Tomas Kasza
Murray A Katelyn
Jessica S Kelsey
Larisa A Kerrigan
Daryl Khaw
Junghee Kim
Justin Z Knutter
Ching-Chung Ko
Gail V Larkin
Jennifer R Laroche
Asma Latif
Kohana D Leuba
Sequoia I Leuba
Lynn O Lewis
Kathryn E Loesser-Casey
Courtney A Long
A Javier Lopez
Nicholas Lowery
Tina Q Lu
Victor Mac
Isaac R Masters
Jazmyn J McCloud
Molly J McDonough
Andrew J Medenbach
Anjali Menon
Rachel Miller
Brandon K Morgan
Patrick C Ng
Elvis Nguyen
Katrina T Nguyen
Emilie T Nguyen
Kaylee M Nicholson
Lindsay A Parnell
Caitlin E Peirce
Allison M Perz
Luke J Peterson
Rachel E Pferdehirt
Seegren V Philip
Kit Pogliano
Joe Pogliano
Tamsen Polley
Erica J Puopolo
Hannah S Rabinowitz
Michael J Resiss
Corwin N Rhyan
Yetta M Robinson
Lauren L Rodriguez
Andrew C Rose
Jeffrey D Rubin
Jessica A Ruby
Margaret S Saha
James W Sandoz
Judith Savitskaya
Dale J Schipper
Christine E Schnitzler
Amanda R Schott
J Bradley Segal
Christopher D Shaffer
Kathryn E Sheldon
Erica M Shepard
Jonathan W Shepardson
Madav K Shroff
Jessica M Simmons
Erika F Simms
Brandy M Simpson
Kathryn M Sinclair
Robert L Sjoholm
Ingrid J Slette
Blaire C Spaulding
Clark L Straub
Joseph Stukey
Trevor Sughrue
Tin-Yun Tang
Lyons M Tatyana
Stephen B Taylor
Barbara J Taylor
Louise M Temple
Jasper V Thompson
Michael P Tokarz
Stephanie E Trapani
Alexander P Troum
Jonathan Tsay
Anthony T Tubbs
Jillian M Walton
Danielle H Wang
Hannah Wang
John R Warner
Emilie G Weisser
Samantha C Wendler
Kathleen A Weston-Hafer
Hilary M Whelan
Kurt E Williamson
Angelica N Willis
Hannah S Wirtshafter
Theresa W Wong
Phillip Wu
Yun jeong Yang
Brandon C Yee
David A Zaidins
Bo Zhang
Melina Y Zúniga
Roger W Hendrix
Graham F Hatfull
Carnegie Mellon University · USUniversity of California, San Diego · USHope College · USJames Madison University · USUniversity of California, Santa Cruz · USWashington University in St. Louis · USOregon State University · USUniversity of Mary Washington · USUniversity of Pittsburgh · USSpelman College · USUniversity of Louisiana at Monroe · USWilliam & Mary · USWilliams (United States) · USHoward Hughes Medical Institute · USUniversity of Maryland, Baltimore · USUniversity of Baltimore · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
FORESPORE ENGULFMENT DURING B SUBTILIS SPORULATIONR01GM057045 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POGLIANO, KIT J · 1998 to 2021
$6.1M
GENOMIC ANALYSIS OF LAMBDOID, TB &OTHER BACTERIOPHAGESR01GM051975 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HENDRIX, ROGER W · 1995 to 2007
$2.4M
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR000005NIGMS NIH HHS GM51975NIGMS NIH HHS R01 GM051975NIGMS NIH HHS R01 GM057045
6 · The paper itself

Abstract

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.

Indexed as

Biological EvolutionGenetic VariationBase SequenceDNA, ViralGenome, ViralGeographyMycobacteriophagesSequence Analysis, DNAUnited StatesDNA, Viral

Identifiers

PMID21298013
PMCPMC3029335
OpenAlexW2108377979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.