ArticlePloS one2011
Pituitary stalk interruption syndrome: diagnostic delay and sensitivity of the auxological criteria of the growth hormone research society.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Phenotypic heterogeneity in pediatric pituitary stalk interruption syndrome: greater disease burden in the metabolic-onset phenotype.Translational pediatrics · 2026Article
- Development, internal and external evaluation of an artificial intelligence algorithm for child growth monitoring in primary care.PLOS digital health · 2026Article
- New French height velocity growth charts: An innovative big-data approach based on routine measurements.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Presentation and diagnosis of childhood-onset combined pituitary hormone deficiency: A single center experience from over 30 years.EClinicalMedicine · 2022Article
- Evaluating the sensitivity and specificity of the UK and Dutch growth referral criteria in predicting the diagnosis of pathological short stature.BMJ paediatrics open · 2022Observational
- Age at diagnosis in patients with chronic congenital endocrine conditions: a regional cohort study from a reference center for rare diseases.Orphanet journal of rare diseases · 2021Observational
- Important Tools for Use by Pediatric Endocrinologists in the Assessment of Short StatureJournal of clinical research in pediatric endocrinology · 2021Review
- Pattern and Features of Pediatric Endocrinology Referrals: A Retrospective Study in a Single Tertiary Center in Italy.Frontiers in pediatrics · 2020Article
- MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions.Experimental and therapeutic medicine · 2017Article
- High-resolution heavily T2-weighted magnetic resonance imaging for evaluation of the pituitary stalk in children with ectopic neurohypophysis.Pediatric radiology · 2017Article
- Priority target conditions for algorithms for monitoring children's growth: Interdisciplinary consensus.PloS one · 2017Article
- Short Stature Diagnosis and Referral.Frontiers in endocrinology · 2017Article
- Article
- Pituitary stalk interruption syndrome presenting as short stature: a case report.Journal of medical case reports · 2014Article
- Diagnostic value of provocative test by insulin combined with clonidine for growth hormone deficiency in children.Iranian journal of pediatrics · 2013Article
- Growth monitoring: a survey of current practices of primary care paediatricians in Europe.PloS one · 2013Article
- Pituitary stalk interruption syndrome in Chinese people: clinical characteristic analysis of 55 cases.PloS one · 2013Article
- Pituitary stalk interruption syndrome in 53 postpubertal patients: factors influencing the heterogeneity of its presentation.PloS one · 2013Article
- Diagnosis of growth hormone deficiency in childhood.Current opinion in endocrinology, diabetes, and obesity · 2012Review
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4 authors.
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Abstract
objectivesTo study the diagnostic delay for pituitary stalk interruption syndrome (PSIS) with growth hormone deficiency (GHD) and the sensitivity of the auxological criteria of the Growth Hormone Research Society (GHRS) consensus guidelines.
methodsA single-center retrospective case-cohort study covering records from January 2000 through December 2007 evaluated the performance of each GHRS auxological criterion for patients with GHD and PSIS. Diagnostic delay was calculated as the difference between the age at which the earliest GHRS criterion could have been observed and the age at diagnosis of PSIS with GHD. A diagnostic delay exceeding one year was defined as late diagnosis.
resultsThe study included 21 patients, 16 (76%) of whom had isolated GHD and 5 (24%) multiple pituitary hormone deficiencies. The median age at diagnosis was 3.6 years (interquartile range, IQR, 2.6-5.5). The median diagnostic delay was 2.3 years (range 0-12.6; IQR 1.5-3.6), with late diagnosis for 17 patients (81%). Height more than 1.5 SDS below target height was the most effective criterion: 90% of the patients met the criterion before diagnosis at a median age of 1 year, and it was the first criterion to be fulfilled for 84%.
conclusionIn our cohort, the delay for diagnosis of PSIS with GHD was long and could have been reduced by using the GHRS criteria, in particular, height more than 1.5 SDS below the target height. The specificity of such a strategy needs to be tested in healthy populations.
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