ArticlePloS one2011
Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Gene expression profiling-based identification of CD28 and PI3K as new biomarkers for chronic graft-versus-host disease.DNA and cell biology · 2011Trial
- Article
- Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia.Scientific reports · 2019Article
- Rapid progression to AML in a patient with germlineLeukemia research reports · 2019Article
- Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1.PloS one · 2016Article
- Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.Experimental hematology · 2015Article
- Article
- Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.Leukemia · 2014Article
- Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.Oncogene · 2013Article
- Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.Nature cell biology · 2013Article
- Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.Nucleic acids research · 2012Review
- Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF).Cancer cell international · 2012Article
- GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia.The international journal of biochemistry & cell biology · 2012Review
- Genome-scale technology driven advances to research into normal and malignant haematopoiesis.Scientifica · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Acute leukaemias are commonly caused by mutations that corrupt the transcriptional circuitry of haematopoietic stem/progenitor cells. However, the mechanisms underlying large-scale transcriptional reprogramming remain largely unknown. Here we investigated transcriptional reprogramming at genome-scale in mouse retroviral transplant models of acute myeloid leukaemia (AML) using both gene-expression profiling and ChIP-sequencing. We identified several thousand candidate regulatory regions with altered levels of histone acetylation that were characterised by differential distribution of consensus motifs for key haematopoietic transcription factors including Gata2, Gfi1 and Sfpi1/Pu.1. In particular, downregulation of Gata2 expression was mirrored by abundant GATA motifs in regions of reduced histone acetylation suggesting an important role in leukaemogenic transcriptional reprogramming. Forced re-expression of Gata2 was not compatible with sustained growth of leukaemic cells thus suggesting a previously unrecognised role for Gata2 in downregulation during the development of AML. Additionally, large scale human AML datasets revealed significantly higher expression of GATA2 in CD34+ cells from healthy controls compared with AML blast cells. The integrated genome-scale analysis applied in this study represents a valuable and widely applicable approach to study the transcriptional control of both normal and aberrant haematopoiesis and to identify critical factors responsible for transcriptional reprogramming in human cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.