ArticlePloS one2011
Label-free proteomics reveals decreased expression of CD18 and AKNA in peripheral CD4+ T cells from patients with Vogt-Koyanagi-Harada syndrome.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- Critical Role of the Transcription Factor AKNA in T-Cell Activation: An Integrative Bioinformatics Approach.International journal of molecular sciences · 2023Article
- Article
- Functional Role of AKNA: A Scoping Review.Biomolecules · 2021Article
- Protein Biomarkers in Uveitis.Frontiers in immunology · 2020Review
- Differential proteomic analysis of serum exosomes reveals alterations in progression of Parkinson disease.Medicine · 2019Article
- Article
- Autoimmune and autoinflammatory mechanisms in uveitis.Seminars in immunopathology · 2014Review
- Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Translational vitreous proteomics.Proteomics. Clinical applications · 2014Article
- Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer.Journal of translational medicine · 2014Review
- Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient.Molecular vision · 2014Article
- Identification of nucleolin as a lipid-raft-dependent β1-integrin-interacting protein in A375 cell migration.Molecules and cells · 2013Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vogt-Koyanagi-Harada (VKH) syndrome is a systemic autoimmune disease. CD4(+) T cells have been shown to be involved in autoimmune diseases including VKH syndrome. To screen aberrantly expressed membrane proteins in CD4(+) T cell from patients with active VKH syndrome, blood samples were taken from five patients with active VKH syndrome and five healthy individuals. A label-free quantitative proteomic strategy was used to identify the differently expressed proteins between the two groups. The results revealed that the expression of 102 peptides was significantly altered (p<0.05) between two groups and matched amino acid sequences of proteins deposited in the international protein index (ipi.HUMAN.v3.36.fasta). The identified peptides corresponded to 64 proteins, in which 30 showed more than a 1.5-fold difference between the two groups. The decreased expression of CD18 and AKNA transcription factor (AKNA), both being three-fold lower than controls in expression identified by the label-free method, was further confirmed in an additional group of five active VKH patients and six normal individuals using the Western blot technique. A significantly decreased expression of CD18 and AKNA suggests a role for both proteins in the pathogenesis of this syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.