ArticleJournal of clinical biochemistry and nutrition2011
Mysterious link between iron overload and CDKN2A/2B.
Article in Journal of clinical biochemistry and nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Computational Analysis of Iron-binding Proteins in the Mutational Landscape of Cancer.Biological trace element research · 2026Article
- Ferroptosis and cancer: when iron turns against tumors.Cellular and molecular life sciences : CMLS · 2025Review
- Identifying key targets and immune environment in wound healing based on iron overload-related genes.Archives of dermatological research · 2025Article
- Neoadjuvant immunology therapy in patients with non-small cell lung cancer and chronic obstructive pulmonary disease.Journal of thoracic disease · 2024Article
- Article
- A novel MRI-based deep learning networks combined with attention mechanism for predicting CDKN2A/B homozygous deletion status in IDH-mutant astrocytoma.European radiology · 2024Article
- Iron as spirit of life to share under monopoly.Journal of clinical biochemistry and nutrition · 2022Article
- Altered pathways and targeted therapy in double hit lymphoma.Journal of hematology & oncology · 2022Review
- Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis.Cancer science · 2022Article
- Construction of a ferroptosis-related eight gene signature for predicting the prognosis and immune infiltration of thyroid cancer.Frontiers in endocrinology · 2022Article
- Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles.Journal of cancer prevention · 2021Review
- Efficacy of Polyphenols in the Management of Dyslipidemia: A Focus on Clinical Studies.Nutrients · 2021Review
- Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.Cancers · 2020Review
- Ferroptosis at the crossroads of infection, aging and cancer.Cancer science · 2020Review
- Dietary and Sentinel Factors Leading to Hemochromatosis.Nutrients · 2019Review
- Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2017Article
- Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis.Cancer science · 2016Article
- Checkpoint kinase 1 inhibitors as targeted molecular agents for clear cell carcinoma of the ovary.Oncology letters · 2015Article
- METABOLISM OF IRON STORES.Nagoya journal of medical science · 2014Review
- Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis.Redox report : communications in free radical research · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent oxidative stress has been associated with carcinogenesis. Iron overload is considered one such condition that causes oxidative stress. Epidemiological studies support a close link between iron overload and carcinogenesis. Reportedly, regular semiannual phlebotomies reduced cancer risk in an otherwise normal population. More specifically, genetic hemochromatosis, chronic viral hepatitis, ovarian endometriosis and asbestosis induce iron overload, which can lead to hepatocellular carcinoma, ovarian carcinoma or mesothelioma in humans. Through a combination of animal experiments and microarray analyses, homozygous deletion of CDKN2A/2B has been recognized as one of the major target genes involved in iron overload-induced carcinogenesis. CDKN2A/2B are the second most frequently inactivated tumor suppressing genes in human cancers. Currently, when infection is becoming sufficiently controlled worldwide, iron regulation may be the next target for human longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.