Evidence map›Paper›PMID 21297878›Full record

ArticleExpert review of endocrinology & metabolism2010

Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity.

Michael A Valentino, Francheska Colon-Gonzalez, Jieru E Lin, Scott A Waldman

Open access · greenAbstract read
In one paragraph

Article in Expert review of endocrinology & metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael A ValentinoDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA.
Francheska Colon-Gonzalez
Jieru E Lin
Scott A Waldman
Thomas Jefferson University · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI William K. Kelly · 1995 to 2026
$94.8M
CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
Guanylyl Cyclase C in Blood and Colorectal CancerR01CA095026 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2003 to 2008
$5.1M
GUANYLYL CYCLASE C AS A BIOMARKER FOR COLORECTAL CANCERR01CA075123 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A. · 1998 to 2006
$5.1M
Training Program in Human InvestigationK30RR022299 · NCRR · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2005 to 2009
$1.5M
Occult lymph node metastases and racial disparities in colon cancer outcomesRC1CA146033 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2009 to 2010
$997k
NCI NIH HHS P30 CA056036NCI NIH HHS R01 CA075123NCI NIH HHS R01 CA095026NCI NIH HHS RC1 CA146033NCRR NIH HHS K30 RR022299NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

With the eruption of the obesity pandemic over the past few decades, much research has been devoted to understanding the molecular mechanisms by which the human body regulates energy balance. These studies have revealed several mediators, including gut/pancreatic/adipose hormones and neuropeptides that control both short- and long-term energy balance by regulating appetite and/or metabolism. These endogenous mediators of energy balance have been the focus of many anti-obesity drug-development programs aimed at either amplifying endogenous anorexigenic/lipolytic signaling or blocking endogenous orexigenic/lipogenic signaling. Here, we discuss the efficacy and safety of targeting these pathways for the pharmacologic treatment of obesity.

Identifiers

PMID21297878
PMCPMC3032596
OpenAlexW2022055557

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.