SynthesisNature genetics2011
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Erratum issuedOpen access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 726 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
726citing papers in PubMed, 7 pooled it
102.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
726 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,348 citations in OpenAlex.
- Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study.Scientific reports · 2025Pooled it
- Inflammatory bowel disease and risk of autoimmune hepatitis: A univariable and multivariable Mendelian randomization study.PloS one · 2024Pooled it
- Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort.Human molecular genetics · 2023Pooled it
- Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin.Genome biology · 2022Pooled it
- A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.Communications biology · 2022Pooled it
- Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.Nature communications · 2021Pooled it
- Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles atInternational journal of molecular sciences · 2020Pooled it
- Family-based genome-wide association study of leprosy in Vietnam.PLoS pathogens · 2020Trial
- Targeting Interleukin-7 Signalling in Ulcerative Colitis: Rationale and Emerging Clinical Evidence.Life (Basel, Switzerland) · 2026Review
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- Article
- Ulcerative colitis: from molecular pathophysiology to management and the emerging role of natural and pharmacological drug candidates.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- MicroRNAs as novel therapeutic targets against inflammatory bowel disease through modulation of ferroptosis.Clinical and experimental medicine · 2026Review
- Special Issue: "Advances in Molecular Research on Autoimmune Diseases, 2nd Edition".International journal of molecular sciences · 2026Article
- REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREM.bioRxiv : the preprint server for biology · 2026Article
- YDJC restrains Th1 cell differentiation by blocking SREBP2-mediated cholesterol biosynthesis to alleviate mucosal inflammation in inflammatory bowel disease.Cellular & molecular immunology · 2026Article
- Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay.Brain communications · 2026Article
- From Polymorphisms to Phenotypes:Genes · 2025Article
- Repurposing liraglutide to the management of DSS-induced colitis: a potential for promoting autophagy.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
666 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
113 authors at 20 institutions in 18 countries.
Carl A AndersonWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Gabrielle Boucher
Charlie W Lees
Andre Franke
Mauro D'Amato
Kent D Taylor
James C Lee
Philippe Goyette
Marcin Imielinski
Anna Latiano
Caroline Lagacé
Regan Scott
Leila Amininejad
Suzannah Bumpstead
Leonard Baidoo
Robert N Baldassano
Murray Barclay
Theodore M Bayless
Stephan Brand
Carsten Büning
Jean-Frédéric Colombel
Lee A Denson
Martine De Vos
Marla Dubinsky
Cathryn Edwards
David Ellinghaus
Rudolf S N Fehrmann
James A B Floyd
Timothy Florin
Denis Franchimont
Lude Franke
Michel Georges
Jürgen Glas
Nicole L Glazer
Stephen L Guthery
Talin Haritunians
Nicholas K Hayward
Jean-Pierre Hugot
Gilles Jobin
Debby Laukens
Ian Lawrance
Marc Lémann
Arie Levine
Cecile Libioulle
Edouard Louis
Dermot P McGovern
Monica Milla
Grant W Montgomery
Katherine I Morley
Craig Mowat
Aylwin Ng
William Newman
Roel A Ophoff
Laura Papi
Orazio Palmieri
Laurent Peyrin-Biroulet
Julián Panés
Anne Phillips
Natalie J Prescott
Deborah D Proctor
Rebecca Roberts
Richard Russell
Paul Rutgeerts
Jeremy Sanderson
Miquel Sans
Philip Schumm
Frank Seibold
Yashoda Sharma
Lisa A Simms
Mark Seielstad
A Hillary Steinhart
Stephan R Targan
Leonard H van den Berg
Morten Vatn
Hein Verspaget
Thomas Walters
Cisca Wijmenga
David C Wilson
Harm-Jan Westra
Ramnik J Xavier
Zhen Z Zhao
Cyriel Y Ponsioen
Vibeke Andersen
Leif Torkvist
Maria Gazouli
Nicholas P Anagnou
Tom H Karlsen
Limas Kupcinskas
Jurgita Sventoraityte
John C Mansfield
Subra Kugathasan
Mark S Silverberg
Jonas Halfvarson
Jerome I Rotter
Christopher G Mathew
Anne M Griffiths
Richard Gearry
Tariq Ahmad
Steven R Brant
Mathias Chamaillard
Jack Satsangi
Judy H Cho
Stefan Schreiber
Mark J Daly
Jeffrey C Barrett
Miles Parkes
Vito Annese
Hakon Hakonarson
Graham Radford-Smith
Richard H Duerr
Séverine Vermeire
Rinse K Weersma
John D Rioux
Cedars-Sinai Medical Center · USQIMR Berghofer Medical Research Institute · AUUniversity Medical Center Groningen · NLWellcome Sanger Institute · GBChildren's Hospital of Philadelphia · USKiel University · DEUniversity of Otago · NZUniversity of Pittsburgh · USYale University · USCasa Sollievo della Sofferenza · ITCentre Hospitalier Universitaire de Liège · BEConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESErasmus Hospital · BEGhent University Hospital · BEJohns Hopkins Medicine · USKarolinska Institutet · SEKing's College London · GBMassachusetts General Hospital · USMontreal Heart Institute · CANational and Kapodistrian University of Athens · GR
Funding
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MUsing polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1MInflammatory Bowel Disease Genetics Consortium Data Coordinating CenterU01DK062429 · NIDDK · YALE UNIVERSITY · PI CHO, JUDY H. · 2002 to 2016
$16.8MPrecision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBDU24DK062429 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ling-shiang Chuang, Ron Do · 2017 to 2026
$13.9MUtilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2MYale University Inflammatory Bowel Disease Genetics Research CenterU01DK062422 · NIDDK · YALE UNIVERSITY · PI Ling-shiang Chuang · 2002 to 2026
$10.8MIBD Gene Mapping by Clinical and Population SubsetsU01DK062431 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Steven R Brant · 2002 to 2026
$10.7MUniversite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6MChief Scientist Office CZB/4/540Medical Research Council G0600329Medical Research Council G0800675Medical Research Council G0800759Medical Research Council G1002033NCATS NIH HHS UL1 TR000005NCRR NIH HHS M01 RR000425NCRR NIH HHS M01-RR00425NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS R01 HL087652NHLBI NIH HHS U01 HL080295NIAID NIH HHS AI062773NIAID NIH HHS R01 AI062773NIDDK NIH HHS DK043351NIDDK NIH HHS DK062413NIDDK NIH HHS DK062420NIDDK NIH HHS DK062422NIDDK NIH HHS DK062423NIDDK NIH HHS DK062429NIDDK NIH HHS DK062431NIDDK NIH HHS DK062432NIDDK NIH HHS DK 063491NIDDK NIH HHS DK064869NIDDK NIH HHS DK069513NIDDK NIH HHS DK076984NIDDK NIH HHS DK084554NIDDK NIH HHS DK83756NIDDK NIH HHS K23 DK069513NIDDK NIH HHS P01 DK046763NIDDK NIH HHS P01-DK046763NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK060049NIDDK NIH HHS R01 DK064869NIDDK NIH HHS R01 DK083756NIDDK NIH HHS R03 DK076984NIDDK NIH HHS R21 DK084554NIDDK NIH HHS U01 DK062413NIDDK NIH HHS U01 DK062420NIDDK NIH HHS U01 DK062422NIDDK NIH HHS U01 DK062423NIDDK NIH HHS U01 DK062429NIDDK NIH HHS U01 DK062431NIDDK NIH HHS U01 DK062432NIDDK NIH HHS U24 DK062429Wellcome TrustWellcome Trust 083948/Z/07/ZWellcome Trust WT089120/Z/09/ZWellcome Trust WT091745/Z/10/Z
Abstract
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
Indexed as
Colitis, UlcerativeCrohn DiseaseGenome-Wide Association StudyHumansRisk
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