ArticleNature biotechnology2011
Fluorescent peptides highlight peripheral nerves during surgery in mice.
Article in Nature biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 3 of them syntheses that pooled it.
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Who cites it
109 citing papers in PubMed, 3 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Evolution in optical molecular imaging techniques guided nerve imaging from 2009 to 2023: a bibliometric and visualization analysis.Frontiers in neurology · 2024Pooled it
- Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance.Pharmacological research · 2021Pooled it
- Near-infrared fluorescence imaging for real-time intraoperative anatomical guidance in minimally invasive surgery: a systematic review of the literature.World journal of surgery · 2015Pooled it
- Near-infrared intraoperative imaging of pelvic autonomic nerves: a pilot study.Surgical endoscopy · 2022Trial
- Spatio-temporally modulated fluorescence imager for intraoperative nerve identification.Journal of biomedical optics · 2026Article
- A nanozyme-augmented peripheral nerve-targeting liposome alleviates local immune inflammation and ferroptosis for enhanced facial nerve repair.Materials today. Bio · 2026Article
- Localizing Nerve Injury, Defining Injury Severity, and Estimating Prognosis (Nerve SPACE 2025).Journal of hand surgery global online · 2026Article
- Fluorescence Guided Surgery in Gastric Cancer: What Do We Have and What Can We Do?Annals of gastroenterological surgery · 2025Review
- Intraoperative nerve-specific fluorescence visualization in head and neck surgery: a Phase 1 trial.Nature communications · 2025Article
- Targeted intervention in nerve-cancer crosstalk enhances pancreatic cancer chemotherapy.Nature nanotechnology · 2025Article
- Two-color fluorescence-guided surgery for head and neck cancer resections.Journal of biomedical optics · 2025Article
- Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024Review
- Shining a Light on Venom-Peptide Receptors: Venom Peptides as Targeted Agents for In Vivo Molecular Imaging.Toxins · 2024Review
- NIR-II light in clinical oncology: opportunities and challenges.Nature reviews. Clinical oncology · 2024Review
- Construction of Targeting-Peptide-Based Imaging Reagents and Their Application in Bioimaging.Chemical & biomedical imaging · 2024Review
- NabioRxiv : the preprint server for biology · 2024Article
- Raman difference spectroscopy and U-Net convolutional neural network for molecular analysis of cutaneous neurofibroma.PloS one · 2024Article
- Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment.Nature communications · 2023Article
- [Near-infrared targeted probe designed for intraoperative imaging of prostatic neurovascular bundles].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging.Current opinion in chemical biology · 2023Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Nerve preservation is an important goal during surgery because accidental transection or injury leads to significant morbidity, including numbness, pain, weakness or paralysis. Nerves are usually identified by their appearance and relationship to nearby structures or detected by local electrical stimulation (electromyography), but thin or buried nerves are sometimes overlooked. Here, we use phage display to select a peptide that binds preferentially to nerves. After systemic injection of a fluorescently labeled version of the peptide in mice, all peripheral nerves are clearly delineated within 2 h. Contrast between nerve and adjacent tissue is up to tenfold, and useful contrast lasts up to 8 h. No changes in behavior or activity are observed after treatment, indicating a lack of obvious toxicity. The fluorescent probe also labels nerves in human tissue samples. Fluorescence highlighting is independent of axonal integrity, suggesting that the probe could facilitate surgical repair of injured nerves and help prevent accidental transection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.