Evidence map›Paper›PMID 21297016›Full record

ArticleJournal of dental research2011

Genetic diversity of plaque mutans streptococci with rep-PCR.

K Cheon, S A Moser, J Whiddon, R C Osgood, S Momeni, J D Ruby, G R Cutter, D B Allison, N K Childers

Abstract read
In one paragraph

Article in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Intraspecies interactions ofbioRxiv : the preprint server for biology · 2023
    Article
  3. Genotypic and phenotypic characterization ofIranian journal of microbiology · 2021
    Article
  4. Article
  5. Quantification of Human Oral and FecalFrontiers in microbiology · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

K CheonDepartment of Pediatric Dentistry, University of Alabama School of Dentistry, 1919 7th Avenue South, Birmingham, AL 35294, USA.
S A Moser
J Whiddon
R C Osgood
S Momeni
J D Ruby
G R Cutter
D B Allison
N K Childers
University of Alabama · USUniversity of Alabama at Birmingham · USRochester Institute of Technology · US

Funding

Epidemiology of Dental Caries and Immunity in ChildrenR01DE016684 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHILDERS, NOEL K · 2006 to 2013
$6.8M
Dental Academic Research Training - DARTT32DE017607 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MACDOUGALL, MARY · 2007 to 2011
$3.2M
NIDCR NIH HHS DE016684NIDCR NIH HHS DE017607NIDCR NIH HHS R01 DE016684NIDCR NIH HHS T32 DE017607
6 · The paper itself

Abstract

Mutans streptococci (MS) are key organisms associated with the etiology of dental caries. Using probabilities that were tested by oversampling, we designed this study to determine the minimal number of MS isolates from an individual required to evaluate diversity of genotypes. MS isolates were genotyped by repetitive extragenic palindromic-polymerase chain-reaction (rep-PCR). Analysis of 20 isolates from individuals resulted in a mean of 1.6 and 2.4 genotypes in children (N = 12) and adults (N = 10), respectively. In a follow-up study, reducing the number of isolates to 7-10 resulted in a theoretical probability of up to 78% for detecting up to 4 genotypes. A mean of 1.5 genotypes was found in 35 children and 10 adults. These findings provide evidence for the design of studies of MS genotyping that can serve as a model for the analysis of genotypes within individuals.

Indexed as

AdultBacterial Typing TechniquesChildChild, PreschoolDental PlaqueDNA, BacterialDNA FingerprintingGene LibraryGenetic VariationGenotypeHumansModels, GeneticOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionProbabilityRepetitive Sequences, Nucleic AcidDNA, Bacterial

Identifiers

PMID21297016
PMCPMC3088998
OpenAlexW2055429055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.