ArticleThe Journal of biological chemistry2011
Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- The diversity of substrates for plant respiration and how to optimize their use.Plant physiology · 2023Review
- Effects of Poty-Potexvirus Synergism on Growth, Photosynthesis and Metabolite Status ofViruses · 2022Article
- SlS5H silencing reveals specific pathogen-triggered salicylic acid metabolism in tomato.BMC plant biology · 2022Article
- Genome-wide association of the metabolic shifts underpinning dark-induced senescence in Arabidopsis.The Plant cell · 2022Article
- Proteomic and metabolomic analysis of Nicotiana benthamiana under dark stress.FEBS open bio · 2022Article
- A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.Nature communications · 2021Article
- Evolution of the Cytokinin Dehydrogenase (CKX) Domain.Journal of molecular evolution · 2021Article
- Origin and Function of Structural Diversity in the Plant Specialized Metabolome.Plants (Basel, Switzerland) · 2021Review
- The phosphorylated pathway of serine biosynthesis links plant growth with nitrogen metabolism.Plant physiology · 2021Article
- Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.Cell discovery · 2021Article
- An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.Nature communications · 2020Article
- Primary Metabolite Responses to Oxidative Stress in Early-Senescing and Paraquat ResistantFrontiers in plant science · 2020Article
- Lysine, Lysine-Rich, Serine, and Serine-Rich Proteins: Link Between Metabolism, Development, and Abiotic Stress Tolerance and the Role of ncRNAs in Their Regulation.Frontiers in plant science · 2020Review
- Proline oxidation fuels mitochondrial respiration during dark-induced leaf senescence in Arabidopsis thaliana.Journal of experimental botany · 2019Article
- TAT1 and TAT2 tyrosine aminotransferases have both distinct and shared functions in tyrosine metabolism and degradation inThe Journal of biological chemistry · 2019Article
- Molecular Mechanisms Preventing Senescence in Response to Prolonged Darkness in a Desiccation-Tolerant Plant.Plant physiology · 2018Article
- Snf1-RELATED KINASE1-Controlled C/SThe Plant cell · 2018Article
- Commonalities and differences in plants deficient in autophagy and alternative pathways of respiration on response to extended darkness.Plant signaling & behavior · 2017Article
- Autophagy Deficiency Compromises Alternative Pathways of Respiration following Energy Deprivation inPlant physiology · 2017Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
D-2-Hydroxyglutarate dehydrogenase (D-2HGDH) catalyzes the specific and efficient oxidation of D-2-hydroxyglutarate (D-2HG) to 2-oxoglutarate using FAD as a cofactor. In this work, we demonstrate that D-2HGDH localizes to plant mitochondria and that its expression increases gradually during developmental and dark-induced senescence in Arabidopsis thaliana, indicating an enhanced demand of respiration of alternative substrates through this enzymatic system under these conditions. Using loss-of-function mutants in D-2HGDH (d2hgdh1) and stable isotope dilution LC-MS/MS, we found that the D-isomer of 2HG accumulated in leaves of d2hgdh1 during both forms of carbon starvation. In addition to this, d2hgdh1 presented enhanced levels of most TCA cycle intermediates and free amino acids. In contrast to the deleterious effects caused by a deficiency in D-2HGDH in humans, d2hgdh1 and overexpressing lines of D-2HGDH showed normal developmental and senescence phenotypes, indicating a mild role of D-2HGDH in the tested conditions. Moreover, metabolic fingerprinting of leaves of plants grown in media supplemented with putative precursors indicated that D-2HG most probably originates during the catabolism of lysine. Finally, the L-isomer of 2HG was also detected in leaf extracts, indicating that both chiral forms of 2HG participate in plant metabolism.
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