ArticleMolecular cancer research : MCR2011
Batf promotes growth arrest and terminal differentiation of mouse myeloid leukemia cells.
Article in Molecular cancer research : MCR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorγT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung.Scientific reports · 2014Trial
- Review
- Identification of novel DNA sequence motifs that modulate transcription in T cells.BMC genomics · 2026Article
- The role of BATF in immune cell differentiation and autoimmune diseases.Biomarker research · 2025Review
- Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling.International journal of molecular sciences · 2023Article
- Diagnostic and prognostic role of basic leucine zipper transcription factor in kidney renal clear cell carcinoma.Translational andrology and urology · 2022Article
- LncRNA Hmrhl regulates expression of cancer related genes in chronic myelogenous leukemia through chromatin association.NAR cancer · 2021Article
- Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.Cell death & disease · 2021Article
- Beta cell-specific CD8Nature immunology · 2020Article
- Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.Journal of experimental & clinical cancer research : CR · 2019Article
- Article
- BATF regulates the expression of Nfil3, Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice.European journal of immunology · 2018Article
- Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B.Clinical and experimental medicine · 2018Article
- Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226.Immune network · 2015Article
- Identifying module biomarker in type 2 diabetes mellitus by discriminative area of functional activity.BMC bioinformatics · 2015Article
- Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia.Molecular and cellular biology · 2014Article
- STAT3 targets suggest mechanisms of aggressive tumorigenesis in diffuse large B-cell lymphoma.G3 (Bethesda, Md.) · 2013Article
- Th9 cell development requires a BATF-regulated transcriptional network.The Journal of clinical investigation · 2013Article
- BATF regulates the development and function of IL-17 producing iNKT cells.BMC immunology · 2013Article
- Overexpression of Batf induces an apoptotic defect and an associated lymphoproliferative disorder in mice.Cell death & disease · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Batf is a basic leucine zipper transcription factor belonging to the activator protein-1 superfamily. Batf expression is regulated following stimulation of both lymphoid and myeloid cells. When treated with leukemia inhibitory factor, mouse M1 myeloid leukemia cells commit to a macrophage differentiation program that is dependent on Stat3 and involves the induction of Batf gene transcription via the binding of Stat3 to the Batf promoter. RNA interference was employed to block Batf induction in this system and the cells failed to growth arrest or to terminally differentiate. Restoring Batf expression not only reversed the differentiation-defective phenotype but also caused the cells to display signs of spontaneous differentiation in the absence of stimulation. Efforts to define genetic targets of the Batf transcription factor in M1 cells led to the identification of c-myb, a proto-oncogene known to promote blood cell proliferation and to inhibit the differentiation of M1 cells. These results provide strong evidence that Batf mediates the differentiation-inducing effects of Stat3 signaling in M1 cells and suggest that Batf may play a similar role in other blood cell lineages where alterations to the Jak-Stat pathway are hallmarks of disrupted development and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.