ArticleInvestigative ophthalmology & visual science2011
Three-dimensional magnetic resonance imaging of the phakic crystalline lens during accommodation.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 77 citations in OpenAlex.
- Crystalline Lens Shape During Accommodation in Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Crystalline lens geometry from a clinical OCT-based biometer in pre-cataract surgery patients.Research square · 2026Article
- Age-Related Changes in Lens Elasticity Contribute More to Accommodative Decline Than Shape Change.Investigative ophthalmology & visual science · 2025Article
- Refractive index gradient in the lens: reflections on form and function and on the lens paradox.Frontiers in ophthalmology · 2025Review
- Accommodating version of a schematic eye for emmetropia and myopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Isolated human lens interferometric surface radius of curvatures: Implications for the mechanism of accommodation.PloS one · 2025Article
- Optical coherence tomography quantifies gradient refractive index and mechanical stiffness gradient across the human lens.Communications medicine · 2024Article
- Storage-induced mechanical changes of porcine lenses assessed with optical coherence elastography and inverse finite element modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Estimation of the full shape of the crystalline lens from OCT: validation using stretched donor lenses.Biomedical optics express · 2023Article
- Estimation of the full shape of the crystalline lensBiomedical optics express · 2023Article
- New insights in presbyopia: impact of correction strategies.BMJ open ophthalmology · 2023Review
- The Influence of 0.5% Tropicamide on Anterior Segment Parameters With CASIA2 in Emmetropic, Myopic, and Hyperopic Eyes.Frontiers in physiology · 2022Article
- Characterisation and Modelling of an Artificial Lens Capsule Mimicking Accommodation of Human Eyes.Polymers · 2021Article
- An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing.Polymers · 2021Article
- Subtle changes of the crystalline lens after cycloplegia: a retrospective study.BMC ophthalmology · 2021Article
- Increased crystalline lens coverage in optical coherence tomography with oblique scanning and volume stitching.Biomedical optics express · 2021Article
- Article
- Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens.Investigative ophthalmology & visual science · 2020Article
- Anterior Segment Biometry During Accommodation and Effects of Cycloplegics by Swept-Source Optical Coherence Tomography.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation.Investigative ophthalmology & visual science · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo quantify changes in crystalline lens curvature, thickness, equatorial diameter, surface area, and volume during accommodation using a novel two-dimensional magnetic resonance imaging (MRI) paradigm to generate a complete three-dimensional crystalline lens surface model.
methodsNineteen volunteers, aged 19 to 30 years, were recruited. T(2)-weighted MRIs, optimized to show fluid-filled chambers of the eye, were acquired using an eight-channel radio frequency head coil. Twenty-four oblique-axial slices of 0.8 mm thickness, with no interslice gaps, were acquired to visualize the crystalline lens. Three Maltese cross-type accommodative stimuli (at 0.17, 4.0, and 8.0 D) were presented randomly to the subjects in the MRI to examine lenticular changes with accommodation. MRIs were analyzed to generate a three-dimensional surface model.
resultsDuring accommodation, mean crystalline lens thickness increased (F = 33.39, P < 0.001), whereas lens equatorial diameter (F = 24.00, P < 0.001) and surface radii both decreased (anterior surface, F = 21.78, P < 0.001; posterior surface, F = 13.81, P < 0.001). Over the same stimulus range, mean crystalline lens surface area decreased (F = 7.04, P < 0.005) with a corresponding increase in lens volume (F = 6.06, P = 0.005). These biometric changes represent a 1.82% decrease and 2.30% increase in crystalline lens surface area and volume, respectively. CONCLUSIONS; The results indicate that the capsular bag undergoes elastic deformation during accommodation, causing reduced surface area, and the observed volumetric changes oppose the theory that the lens is incompressible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.