ArticleThe American journal of cardiology2011
Relation of baseline systolic blood pressure and long-term outcomes in ambulatory patients with chronic mild to moderate heart failure.
Article in The American journal of cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- Similar clinical benefits from below-target and target dose enalapril in patients with heart failure in the SOLVD Treatment trial.European journal of heart failure · 2018Trial
- Effect of warfarin on outcomes in septuagenarian patients with atrial fibrillation.The American journal of cardiology · 2012Trial
- Clinical Update in Heart Failure with Preserved Ejection Fraction.Current heart failure reports · 2024Review
- Blood pressure and heart failure: focused on treatment.Clinical hypertension · 2024Review
- The Association Between On-treatment Ambulatory Central Blood Pressure and Left Ventricular Reverse Remodeling in Heart Failure With Reduced Ejection Fraction.International journal of heart failure · 2023Article
- The Association Between Beta-blocker and Renin-Angiotensin System Inhibitor Use After Heart Failure With Reduced Ejection Fraction Hospitalization and Outcomes in Older Patients.Journal of cardiac failure · 2023Article
- Predictors and Outcomes of Heart Failure With Preserved Ejection Fraction in Patients With a Left Ventricular Ejection Fraction Above or Below 60.Journal of the American Heart Association · 2022Article
- Article
- Prognostic significance of diastolic blood pressure in patients with heart failure with preserved ejection fraction.Heart and vessels · 2021Article
- Systolic Blood Pressure and Outcomes in Older Patients with HFpEF and Hypertension.The American journal of medicine · 2021Article
- Introduction of sacubitril/valsartan in primary care follow-up of heart failure: a prospective observational study (THESEUS).ESC heart failure · 2020Observational
- Managing Hypertension in the elderly: What's new?American journal of preventive cardiology · 2020Review
- Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.Journal of the American College of Cardiology · 2019Article
- J-shaped curve for cardiovascular mortality: systolic or diastolic blood pressure?Journal of nephrology · 2019Review
- Towards tailoring blood pressure control in HFpEF: Lessons from OPTIMIZE-HF.Global cardiology science & practice · 2019Article
- Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?Current hypertension reports · 2019Review
- Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.JAMA cardiology · 2018Observational
- Emphasis on abdominal obesity as a modifier of eplerenone effect in heart failure: hypothesis-generating signals from EMPHASIS-HF.European journal of heart failure · 2017Article
- Elevation in systolic blood pressure during heart failure hospitalization is associated with increased short and long-term mortality.Medicine · 2017Observational
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
We studied the impact of baseline systolic blood pressure (SBP) on outcomes in patients with mild to moderate chronic systolic and diastolic heart failure (HF) in the Digitalis Investigation Group trial using a propensity-matched design. Of 7,788 patients, 7,785 had baseline SBP data and 3,538 had SBP ≤ 120 mm Hg. Propensity scores for SBP ≤ 120 mm Hg, calculated for each of the 7,785 patients, were used to assemble a matched cohort of 3,738 patients with SBP ≤ 120 and >120 mm Hg who were well-balanced in 32 baseline characteristics. All-cause mortality occurred in 35% and 32% of matched patients with SBPs ≤ 120 and >120 mm Hg respectively, during 5 years of follow-up (hazard ratio [HR] when SBP ≤ 120 was compared to >120 mm Hg 1.10, 95% confidence interval [CI] 0.99 to 1.23, p = 0.088). HRs for cardiovascular and HF mortalities associated with SBP ≤ 120 mm Hg were 1.15 (95% CI 1.01 to 1.30, p = 0.031) and 1.30 (95% CI 1.08 to 1.57, p = 0.006). Cardiovascular hospitalization occurred in 53% and 49% of matched patients with SBPs ≤ 120 and > 120 mm Hg, respectively (HR 1.13, 95% CI 1.03 to 1.24, p = 0.008). HRs for all-cause and HF hospitalizations associated with SBP ≤ 120 mm Hg were 1.10 (95% CI 1.02 to 1.194, p = 0.017) and 1.21 (95% CI 1.07 to 1.36, p = 0.002). In conclusion, in patients with mild to moderate long-term systolic and diastolic HF, baseline SBP ≤ 120 mm Hg was associated with increased cardiovascular and HF mortalities and all-cause, cardiovascular, and HF hospitalizations that was independent of other baseline characteristics.
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