ArticleNeurobiology of learning and memory2011
Effects of pharmacological manipulations of NMDA-receptors on deliberation in the Multiple-T task.
Article in Neurobiology of learning and memory, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Choice Behaviors and Prefrontal-Hippocampal Coupling Are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Deliberative Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.bioRxiv : the preprint server for biology · 2024Article
- Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Computational validity: using computation to translate behaviours across species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session.Neurobiology of learning and memory · 2020Article
- The perirhinal cortex supports spatial intertemporal choice stability.Neurobiology of learning and memory · 2019Article
- Interplay between Hippocampal Sharp-Wave-Ripple Events and Vicarious Trial and Error Behaviors in Decision Making.Neuron · 2016Article
- Representational changes of latent strategies in rat medial prefrontal cortex precede changes in behaviour.Nature communications · 2016Article
- Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex.Nature reviews. Neuroscience · 2016Review
- Active Inference, epistemic value, and vicarious trial and error.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Vicarious trial and error.Nature reviews. Neuroscience · 2016Review
- Manipulating Decisiveness in Decision Making: Effects of Clonidine on Hippocampal Search Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Hippocampus and subregions of the dorsal striatum respond differently to a behavioral strategy change on a spatial navigation task.Journal of neurophysiology · 2015Article
- Aging impairs deliberation and behavioral flexibility in inter-temporal choice.Frontiers in aging neuroscience · 2015Article
- Complex neural codes in rat prelimbic cortex are stable across days on a spatial decision task.Frontiers in behavioral neuroscience · 2014Article
- The road not taken: neural correlates of decision making in orbitofrontal cortex.Frontiers in neuroscience · 2012Article
- The neural substrates of deliberative decision making: contrasting effects of hippocampus lesions on performance and vicarious trial-and-error behavior in a spatial memory task and a visual discrimination task.Frontiers in behavioral neuroscience · 2012Article
- The hippocampus and exploration: dynamically evolving behavior and neural representations.Frontiers in human neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Both humans and non-human animals have the ability to navigate and make decisions within complex environments. This ability is largely dependent upon learning and memory processes, many of which are known to depend on NMDA-sensitive receptors. When humans come to difficult decisions they often pause to deliberate over their choices. Similarly, rats pause at difficult choice points. This behavior, known as vicarious trial and error (VTE), is hippocampally dependent and entails neurophysiological representations of expectations of future outcomes in hippocampus and downstream structures. In order to determine the dependence of VTE behaviors on NMDA-sensitive receptors, we tested rats on a Multiple-T choice task with a reward-delivery reversal known to elicit VTE. Rats under the influence of NMDA-receptor antagonists (CPP) showed a significant reduction in VTE, particularly at the reward reversal, implying a role for NMDA-sensitive receptors in the generation of vicarious trial and error behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.