ArticleJournal of theoretical biology2011
Modeling the host response to inhalation anthrax.
Article in Journal of theoretical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Mechanistic within-host mathematical model of inhalational anthrax.PLoS computational biology · 2025Article
- Quantifying in vitro B. anthracis growth and PA production and decay: a mathematical modelling approach.NPJ systems biology and applications · 2024Article
- A Stochastic Intracellular Model of Anthrax Infection With Spore Germination Heterogeneity.Frontiers in immunology · 2021Article
- Dangerous Pathogens as a Potential Problem for Public Health.Medicina (Kaunas, Lithuania) · 2020Review
- A mathematical model shows macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance.Journal of theoretical biology · 2020Article
- A Novel Stochastic Multi-Scale Model ofFrontiers in microbiology · 2018Article
- Mathematical Models for Immunology: Current State of the Art and Future Research Directions.Bulletin of mathematical biology · 2016Review
- Computational fluid dynamics modeling ofJournal of aerosol science · 2016Article
- Modeling early events in Francisella tularensis pathogenesis.Frontiers in cellular and infection microbiology · 2014Article
- Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis spores.Antimicrobial agents and chemotherapy · 2014Article
- Inhalational anthrax (Ames aerosol) in naïve and vaccinated New Zealand rabbits: characterizing the spread of bacteria from lung deposition to bacteremia.Frontiers in cellular and infection microbiology · 2012Article
- Deterministic models of inhalational anthrax in New Zealand white rabbits.Biosecurity and bioterrorism : biodefense strategy, practice, and scienceArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Inhalation anthrax, an often fatal infection, is initiated by endospores of the bacterium Bacillus anthracis, which are introduced into the lung. To better understand the pathogenesis of an inhalation anthrax infection, we propose a two-compartment mathematical model that takes into account the documented early events of such an infection. Anthrax spores, once inhaled, are readily taken up by alveolar phagocytes, which then migrate rather quickly out of the lung and into the thoracic/mediastinal lymph nodes. En route, these spores germinate to become vegetative bacteria. In the lymph nodes, the bacteria kill the host cells and are released into the extracellular environment where they can be disseminated into the blood stream and grow to a very high level, often resulting in the death of the infected person. Using this framework as the basis of our model, we explore the probability of survival of an infected individual. This is dependent on several factors, such as the rate of migration and germination events and treatment with antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.