ArticleDevelopmental biology2011
Lineage analysis of micromere 4d, a super-phylotypic cell for Lophotrochozoa, in the leech Helobdella and the sludgeworm Tubifex.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 49 citations in OpenAlex.
- Notch signaling in leech neurogenesis: expression patterns and functional insights in the Glossiphoniid leechAnimal cells and systems · 2026Article
- Hedgehog Signaling during Gut Formation in the Freshwater Leech, Helobdella austinensis.Cells, tissues, organs · 2025Article
- Slit-Robo expression in the leech nervous system: insights into eyespot evolution.Cell & bioscience · 2023Article
- Early mesodermal development in the patellogastropodEvolutionary applications · 2023Article
- Head transcriptome profiling of glossiphoniid leech (Open biology · 2022Article
- Behavioral variation according to feeding organ diversification in glossiphoniid leeches (Phylum: Annelida).Scientific reports · 2021Article
- From spiral cleavage to bilateral symmetry: the developmental cell lineage of the annelid brain.BMC biology · 2019Article
- Spatiotemporal Expression of Anticoagulation FactorInternational journal of molecular sciences · 2019Article
- Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelideLife · 2017Article
- Expression patterns of duplicated snail genes in the leech Helobdella.Development genes and evolution · 2017Article
- Spatiotemporal expression of a twist homolog in the leech Helobdella austinensis.Development genes and evolution · 2017Article
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- Differential expression of conserved germ line markers and delayed segregation of male and female primordial germ cells in a hermaphrodite, the leech helobdella.Molecular biology and evolution · 2014Article
- Developmental biology of the leech Helobdella.The International journal of developmental biology · 2014Article
- Analysis of ciliary band formation in the mollusc Ilyanassa obsoleta.Development genes and evolution · 2013Article
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- Cleavage pattern and fate map of the mesentoblast, 4d, in the gastropod Crepidula: a hallmark of spiralian development.EvoDevo · 2012Article
- Intermediate filament genes as differentiation markers in the leech Helobdella.Development genes and evolution · 2011Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
The super-phylum Lophotrochozoa contains the plurality of extant animal phyla and exhibits a corresponding diversity of adult body plans. Moreover, in contrast to Ecdysozoa and Deuterostomia, most lophotrochozoans exhibit a conserved pattern of stereotyped early divisions called spiral cleavage. In particular, bilateral mesoderm in most lophotrochozoan species arises from the progeny of micromere 4d, which is assumed to be homologous with a similar cell in the embryo of the ancestral lophotrochozoan, more than 650 million years ago. Thus, distinguishing the conserved and diversified features of cell fates in the 4d lineage among modern spiralians is required to understand how lophotrochozoan diversity has evolved by changes in developmental processes. Here we analyze cell fates for the early progeny of the bilateral daughters (M teloblasts) of micromere 4d in the leech Helobdella sp. Austin, a clitellate annelid. We show that the first six progeny of the M teloblasts (em1-em6) contribute five different sets of progeny to non-segmental mesoderm, mainly in the head and in the lining of the digestive tract. The latter feature, associated with cells em1 and em2 in Helobdella, is seen with the M teloblast lineage in a second clitellate species, the sludgeworm Tubifex tubifex and, on the basis of previously published work, in the initial progeny of the M teloblast homologs in molluscan species, suggesting that it may be an ancestral feature of lophotrochozoan development.
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