ArticleJournal of biomedical science2011
Role of taurine on acid secretion in the rat stomach.
Article in Journal of biomedical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Mixing Energy Drinks With Alcohol on Driving-Related Skills.The international journal of neuropsychopharmacology · 2022Trial
- Characterization of calcium sources and downstream signaling pathways following electrical field stimulation of rodent longitudinal esophageal muscle.Frontiers in physiology · 2026Article
- The Dark Side of Energy Drinks: A Comprehensive Review of Their Impact on the Human Body.Nutrients · 2023Review
- A comparative metabolomics study between grain-sized moxibustion and suspended moxibustion on rats with gastric ulcers.Heliyon · 2023Article
- Taurine supplementation enhances endurance capacity by delaying blood glucose decline during prolonged exercise in rats.Amino acids · 2022Article
- A synergy of the nutritional additives taurine and silymarin in salmon farming: evaluation with the CHSE-214 cellular model.Fish physiology and biochemistry · 2020Article
- Adequate supply of dietary taurine stimulates expression of molecular markers of growth and protein turnover in juvenile barramundi (Lates calcarifer).Fish physiology and biochemistry · 2020Article
- Modulatory effects of taurine on jejunal contractility.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTaurine has chemical structure similar to an inhibitory neurotransmitter, γ-aminobutyric acid (GABA). Previous studies on GABA in the stomach suggest GABAergic neuron is involved in acid secretion, but the effects of taurine are poor understood.
methodsThe effects of taurine on acid secretion, signal transduction, and localization of taurinergic neurons were determined in the rat stomach using everted whole stomach, RIA kit and immunohistochemical methods.
resultsWe used antibodies against taurine-synthesizing enzyme, cysteine sulfuric acid decarboxylase (CSAD), and taurine. CSAD- and taurine-positive cells were found in the muscle and mucosal layers. Distributions of CSAD- and taurine-positive cells in both mucosal and muscle layers were heterogeneous in the stomach. Taurine at 10-9~10-4 M induced acid secretion, and the maximum secretion was at 10-5 M, 1.6-fold higher than the spontaneous secretion. Taurine-induced acid secretion was completely inhibited by bicuculline and atropine but not by cimetidine, proglumide, or strychnine. Atropine and tetrodotoxin (TTX) completely inhibited the acid secretion induced by low concentrations of taurine and partially inhibited induced by high concentrations. Verapamil, a calcium blocker agent, inhibited acid output elicited by taurine. We assumed all Ca2+ channels involved in the response to these secretagogues were equally affected by verapamil. Intracellular cAMP (adenosine 3', 5'-monophosphate) in the stomach significantly increased with taurine treatment in a dose-dependent manner. High correlation (r=0.859, p < 0.001) of taurine concentrations with cAMP was observed.
conclusionsOur results demonstrated for the first time in taurine-induced acid secretion due to increase intracellular calcium may act through the A type of GABA receptors, which are mainly located on cholinergic neurons though cAMP pathway and partially on nonneuronal cells in the rat stomach.
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