ArticleProteome science2011
Plasma peptidome profiling of acute hepatitis E patients by MALDI-TOF/TOF.
Article in Proteome science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Multiple Functions of Hepatitis E Virus ORF3.Microorganisms · 2024Review
- Apolipoprotein E, a Crucial Cellular Protein in the Lifecycle of Hepatitis Viruses.International journal of molecular sciences · 2022Review
- Early diagnosis of colorectal cancer via plasma proteomic analysis of CRC and advanced adenomatous polyp.Gastroenterology and hepatology from bed to bench · 2019Article
- ITIH4: Effective Serum Marker, Early Warning and Diagnosis, Hepatocellular Carcinoma.Pathology oncology research : POR · 2018Article
- Application Value of Mass Spectrometry in the Differentiation of Benign and Malignant Liver Tumors.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Apolipoprotein E and protection against hepatitis E viral infection in American non-Hispanic blacks.Hepatology (Baltimore, Md.) · 2015Article
- Article
- Quantitative proteomics identifies host factors modulated during acute hepatitis E virus infection in the swine model.Journal of virology · 2015Article
- Matrix-assisted laser desorption ionization: time of flight mass spectrometry-identified models for detection of ESBL-producing bacterial strains.Medical science monitor basic research · 2014Article
- Proteomic analysis of carbon concentrating chemolithotrophic bacteria Serratia sp. for sequestration of carbon dioxide.PloS one · 2014Article
- Establishment of a Strategy for the Discovery and Verification of Low-Abundance Biomarker Peptides in Plasma Using Two Types of Stable-Isotope Tags.Mass spectrometry (Tokyo, Japan) · 2014Article
- Urinary peptide profiling to differentiate between minimal change disease and focal segmental glomerulosclerosis.PloS one · 2014Article
- Detection of ricin intoxication in mice using serum peptide profiling by MALDI-TOF/MS.International journal of molecular sciences · 2012Article
- Detection of murine toxoplasmosis using magnetic bead-based serum peptide profiling by MALDI-TOF MS.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2012Article
- Detection of Leishmania donovani infection using magnetic beads-based serum peptide profiling by MALDI-TOF MS in mice model.Parasitology research · 2012Article
- Molecular virology of hepatitis E virus.Virus research · 2011Review
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis E is endemic to resource-poor regions, where it manifests as sporadic cases and large waterborne outbreaks. The disease severity ranges from acute self-limited hepatitis with low mortality to fulminant hepatic failure with high mortality. It is believed that the host response plays an important role in determining the progression and outcome of this disease. We profiled the plasma peptidome from hepatitis E patients to discover suitable biomarkers and understand disease pathogenesis.
resultsThe peptidome (< 10 kDa) fraction of plasma was enriched and analyzed by mass spectrometry. A comparative analysis of the peptide pattern of hepatitis E patients versus healthy controls was performed using ClinPro Tools. We generated a peptide profile that could be used for selective identification of hepatitis E cases. We have identified five potential biomarker peaks with m/z values of 9288.6, 7763.6, 4961.5, 1060.572 and 2365.139 that can be used to reliably differentiate between hepatitis E patients and controls with areas under the receiver operating characteristic curve (AUROC) values of 1.00, 0.954, 0.989, 0.960 and 0.829 respectively. A number of proteins involved in innate immunity were identified to be differentially present in the plasma of patients compared to healthy controls.
conclusionsBesides the utility of this approach for biomarker discovery, identification of changes in endogenous peptides in hepatitis E patient plasma has increased our understanding of disease pathogenesis. We have identified peptides in plasma that can reliably distinguish hepatitis E patients from healthy controls. Results from this and an earlier proteomics study are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.