Have the efforts to prevent aspirin-related Reye's syndrome fuelled an increase in asthma?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.BMC pulmonary medicine · 2020
   Pooled it
2. Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults.BMJ open · 2014
   Trial
3. Causal assessment of pharmaceutical treatments: why standards of evidence should not be the same for benefits and harms?Drug safety · 2015
   Article
4. The association between acetaminophen and asthma: is there anything to learn from the upper airways?Current opinion in allergy and clinical immunology · 2014
   Review
5. Safety vs. efficacy assessment of pharmaceuticals: Epistemological rationales and methods.Preventive medicine reports · 2014
   Article

Corrections and comments

• Comment on
  The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort.2011

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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