ReviewExpert opinion on pharmacotherapy2011
Aripiprazole for the treatment of irritability associated with autism.
Review in Expert opinion on pharmacotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pharmacotherapy of restricted/repetitive behavior in autism spectrum disorder:a systematic review and meta-analysis.BMC psychiatry · 2020Pooled it
- Aripiprazole for autism spectrum disorders (ASD).The Cochrane database of systematic reviews · 2016Pooled it
- Aripiprazole for treating irritability in children & adolescents with autism: A systematic review.The Indian journal of medical research · 2015Pooled it
- A head-to-head comparison of aripiprazole and risperidone for safety and treating autistic disorders, a randomized double blind clinical trial.Child psychiatry and human development · 2014Trial
- Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026Review
- Utilization of psychotropic medications in individuals with autism spectrum disorder.BMC psychiatry · 2025Article
- Autism Spectrum Disorder in Children: Early Signs and Therapeutic Interventions.Children (Basel, Switzerland) · 2024Review
- Review
- Practitioner's review: medication for children and adolescents with autism spectrum disorder (ASD) and comorbid conditions.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2021Review
- The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods.Pharmaceutics · 2021Article
- Dopamine in Autism Spectrum Disorders-Focus on D2/D3 Partial Agonists and Their Possible Use in Treatment.Frontiers in psychiatry · 2021Review
- Neuroprotective potential of solanesol in intracerebroventricular propionic acid induced experimental model of autism: Insights from behavioral and biochemical evidence.Toxicology reports · 2019Article
- Prescription Trends of Psychotropics in Children and Adolescents with Autism Based on Nationwide Health Insurance Data.Journal of Korean medical science · 2017Article
- Dose Trends of Aripiprazole from 2004 to 2014 in Psychiatric Inpatients in Korea.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- The role of monoamine oxidase A in aggression: Current translational developments and future challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms.Behavioural neurology · 2016Review
- New experimental treatments for core social domain in autism spectrum disorders.Frontiers in pediatrics · 2014Review
- Pharmacotherapy for the core symptoms in autistic disorder: current status of the research.Drugs · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionIrritability (including tantrums, aggression and moodiness) is often associated with autistic disorder. Children with autism are frequently prescribed atypical antipsychotic medications for these behaviors. Although multiple agents have been found to be effective, the safety and tolerability of each antipsychotic may be the determining factor in its selection. AREAS COVERED: The pharmacokinetics, pharmacodynamics, safety and efficacy data on aripiprazole for the treatment of irritability associated with autism are discussed. Knowledge of the mechanism of action, advantages and disadvantages relative to other atypical antipsychotics, and an appreciation of the efficacy of aripiprazole when used to treat irritability in autism is also explored in this paper. EXPERT OPINION: Aripiprazole may have a more favorable side-effect profile than another commonly prescribed medication, risperidone, because of its unique mechanism of action. It seems to be effective in treating irritability associated with autism, but more research is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.