Evidence map›Paper›PMID 21294651›Full record

ReviewAntioxidants & redox signaling2011

Directed stem cell differentiation by fluid mechanical forces.

Luigi Adamo, Guillermo García-Cardeña

Abstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  11. Article
  12. Review
  13. Redox going with vascular shear stress.Antioxidants & redox signaling · 2011
    Article
  14. Stress and stem cells.Wiley interdisciplinary reviews. Developmental biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Luigi AdamoLaboratory for Systems Biology, Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Guillermo García-Cardeña
Brigham and Women's Hospital · US

Funding

CONTROL OF ENDOTHELIAL IDENTITY BY HEMODYNAMIC FORCESR01HL076686 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARCIA-CARDENA, GUILLERMO · 2004 to 2008
$1.5M
NHLBI NIH HHS R01 HL-076686
6 · The paper itself

Abstract

Stem cell research has opened new and exciting possibilities in the biological and biomedical sciences, and holds great promise of impacting many areas of medicine. However, despite the rapid advancements of the last decade, the precise and efficient differentiation of stem cells into distinct cell types and tissues still remains a major challenge for the field. In an effort to reproduce biologically relevant differentiation niches, or to direct stem cell differentiation into specific cellular fates, many investigators have explored the effect of biomechanical stimulation on pluripotent cells. This review focuses on a particular type of biomechanical force, namely fluid shear stress, and our current knowledge on its ability to direct differentiation and modulate function of embryonic and somatic stem cells.

Indexed as

HydrodynamicsStress, MechanicalAnimalsCell DifferentiationHumansMesenchymal Stem CellsPluripotent Stem CellsShear StrengthStem Cells

Identifiers

PMID21294651
PMCPMC3144423
OpenAlexW2095186006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.