ArticleLab on a chip2011
A microfabricated deformability-based flow cytometer with application to malaria.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 247 citations in OpenAlex.
- A Computationally Efficient Viscoelastic Eukaryotic Cell Model.Annals of biomedical engineering · 2025Article
- Pathophysiological Associations and Measurement Techniques of Red Blood Cell Deformability.Biosensors · 2025Review
- An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells.Scientific reports · 2025Article
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- Microfluidic-based electrically driven particle manipulation techniques for biomedical applications.RSC advances · 2025Review
- Microfluidic Technology for Measuring Mechanical Properties of Single Cells and Its Application.Bioengineering (Basel, Switzerland) · 2024Review
- Biophysical profiling of red blood cells from thin-film blood smears using deep learning.Heliyon · 2024Article
- A miniaturized wash-free microfluidic assay for electrical impedance-based assessment of red blood cell-mediated microvascular occlusion.Biosensors & bioelectronics · 2024Article
- High-throughput single-cell assay for precise measurement of the intrinsic mechanical properties and shape characteristics of red blood cells.Lab on a chip · 2024Article
- The Physics and Manipulation of Dean Vortices in Single- and Two-Phase Flow in Curved Microchannels: A Review.Micromachines · 2023Review
- Numerical Model Validation of the Blood Flow through a Microchannel Hyperbolic Contraction.Micromachines · 2023Article
- Microfluidic techniques for mechanical measurements of biological samples.Biophysics reviews · 2023Review
- Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia.Microsystems & nanoengineering · 2023Article
- Measuring cell deformation by microfluidics.Frontiers in bioengineering and biotechnology · 2023Review
- Article
- Persistent red blood cells retain their ability to move in microcapillaries under high levels of oxidative stress.Communications biology · 2022Article
- Systematic Review: Microfluidics and Plasmodium.Micromachines · 2021Review
- A portable impedance microflow cytometer for measuring cellular response to hypoxia.Biotechnology and bioengineering · 2021Article
- A Cell's Viscoelasticity Measurement Method Based on the Spheroidization Process of Non-Spherical Shaped Cell.Sensors (Basel, Switzerland) · 2021Article
- Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion.Lab on a chip · 2021Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of malaria. Here we introduce an automated microfabricated "deformability cytometer" that measures dynamic mechanical responses of 10(3) to 10(4) individual RBCs in a cell population. Fluorescence measurements of each RBC are simultaneously acquired, resulting in a population-based correlation between biochemical properties, such as cell surface markers, and dynamic mechanical deformability. This device is especially applicable to heterogeneous cell populations. We demonstrate its ability to mechanically characterize a small number of P. falciparum-infected (ring stage) RBCs in a large population of uninfected RBCs. Furthermore, we are able to infer quantitative mechanical properties of individual RBCs from the observed dynamic behavior through a dissipative particle dynamics (DPD) model. These methods collectively provide a systematic approach to characterize the biomechanical properties of cells in a high-throughput manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.