ArticleCell cycle (Georgetown, Tex.)2011
While p73 is essential, p63 is completely dispensable for the development of the central nervous system.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Tissue-specific expression of p73 and p63 isoforms in human tissues.Cell death & disease · 2021Article
- Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Frontiers in cell and developmental biology · 2021Review
- P73 and P63: The siblings that work together in neurodevelopment.Cell cycle (Georgetown, Tex.) · 2015Article
- Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system.Cell cycle (Georgetown, Tex.) · 2015Article
- p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis.Cell death and differentiation · 2014Article
- TAp73 is essential for germ cell adhesion and maturation in testis.The Journal of cell biology · 2014Article
- p53 Family and Cellular Stress Responses in Cancer.Frontiers in oncology · 2014Review
- p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Mechanisms, function and clinical applications of DNp73.Cell cycle (Georgetown, Tex.) · 2013Review
- Tumor suppressive pathways in the control of neurogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.Nature reviews. Cancer · 2013Review
- Article
- Tissue-specific expression of p73 C-terminal isoforms in mice.Cell cycle (Georgetown, Tex.) · 2012Article
- Driving apoptosis-relevant proteins toward neural differentiation.Molecular neurobiology · 2012Review
- Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.The Journal of experimental medicine · 2012Article
- TAp63γ demethylation regulates protein stability and cellular distribution during neural stem cell differentiation.PloS one · 2012Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The ancient p53 paralogs p63 and p73 regulate specific tissue formation, cell survival and cell death via their TA and ΔN isoforms. Targeted disruption of the p73 locus leads to severe defects in the development of the central nervous system (CNS), and p73 has recently been shown to be an essential regulator of neural stem cell maintenance and differentiation in both embryonal and adult neurogenesis. In contrast, global p63-/- mice lack skin and limbs. Moreover, p63 is detectable in embryonic cortex. It has previously been proposed to also play critical pro-death and pro-survival roles in neural precursors of the developing sympathetic and central nervous system, respectively, based on experimental overexpression and siRNA-mediated knockdown of p63. Here we perform an extensive analysis of the developing central nervous system in global p63-/- mice and their wildtype littermates. Brain and spinal cord of embryos and newborn mice were assessed in vivo for neuroanatomy, histology, apoptosis, proliferation, stemness and differentiation, and in vitro for self-renewal and maturation in neurosphere assays. None of these analyses revealed a detectable phenotype in p63-/- mice. Hence, despite the profound impact of p63 on the development of stratified epithelia and limbs, p63 is completely dispensable for proper development of the central nervous system. Thus, despite their strong homology, the non-overlapping tissue specificity of p63 and p73 functions appears more pronounced than previously anticipated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.