ArticleCell cycle (Georgetown, Tex.)2011
Post-translational control of Myc function during differentiation.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Clinical management and therapeutic development for the rare disease rhabdomyosarcoma.Journal of Cancer · 2026Review
- Review
- Calcium-dependent signalling in B-cell lymphomas.Oncogene · 2021Review
- ACYP2 contributes to malignant progression of glioma through promoting CaJournal of experimental & clinical cancer research : CR · 2020Article
- MYC leads the way.Small GTPases · 2020Review
- MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Drosophila Myc: A master regulator of cellular performance.Biochimica et biophysica acta · 2015Review
- Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity.Molecular neurobiology · 2015Article
- Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Stress-induced cleavage of Myc promotes cancer cell survival.Genes & development · 2014Article
- MYC degradation.Cold Spring Harbor perspectives in medicine · 2014Review
- S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines.International journal of oncology · 2014Article
- Control of vertebrate development by MYC.Cold Spring Harbor perspectives in medicine · 2013Review
- Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- N-Myc and L-Myc are essential for hair cell formation but not maintenance.Brain research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Myc proteins are deeply involved in multiple biological processes including cell proliferation, growth, metabolism, apoptosis, differentiation, and tumorigenesis. Paradoxically, Myc proteins have been found to be capable of both inhibiting and facilitating differentiation depending on the biological context. Recently we identified a new mode of Myc regulation in differentiating muscle cells in which c-Myc protein is proteolytically cleaved by calcium-dependent calpains in the cytoplasm. This cleavage serves two purposes. First, it inactivates the transcriptional function of Myc by removing its C-terminus, a region responsible for the interaction of Myc with Max and DNA. Second, it alters cytoskeletal architecture and accelerates muscle differentiation through the activity of the remaining N-terminal cleavage product (termed Myc-nick). Here we discuss the roles and regulation of full-length Myc and Myc-nick in terminal differentiation and propose a model in which calpain-mediated cleavage of Myc operates as a functional switch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.