Evidence map›Paper›PMID 21293008›Full record

ReviewCirculation research2011

Vascular smooth muscle progenitor cells: building and repairing blood vessels.

Mark W Majesky, Xiu Rong Dong, Jenna N Regan, Virginia J Hoglund

Open access · bronzeAbstract readReview
In one paragraph

Review in Circulation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 188 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. WT1Theranostics · 2023
    Article
  13. Review
  14. Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  19. Review
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mark W MajeskySeattle Children's Research Institute, University of Washington, 1900 Ninth Ave, M/S C9S-5, Seattle, WA 98101, USA. mwm84@uw.edu
Xiu Rong Dong
Jenna N Regan
Virginia J Hoglund
University of North Carolina at Chapel Hill · US

Funding

THE CONTRACTILE SYSTEM OF VASCULAR SMOOTH MUSCLEP01HL019242 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI OWENS, GARY K · 1985 to 2009
$16.9M
Hedgehog Signaling in the AdventitiaR01HL093594 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAJESKY, MARK W. · 2009 to 2012
$1.8M
NHLBI NIH HHS HL-19242NHLBI NIH HHS HL-93594NHLBI NIH HHS P01 HL019242NHLBI NIH HHS R01 HL093594
6 · The paper itself

Abstract

Molecular pathways that control the specification, migration, and number of available smooth muscle progenitor cells play key roles in determining blood vessel size and structure, capacity for tissue repair, and progression of age-related disorders. Defects in these pathways produce malformations of developing blood vessels, depletion of smooth muscle progenitor cell pools for vessel wall maintenance and repair, and aberrant activation of alternative differentiation pathways in vascular disease. A better understanding of the molecular mechanisms that uniquely specify and maintain vascular smooth muscle cell precursors is essential if we are to use advances in stem and progenitor cell biology and somatic cell reprogramming for applications directed to the vessel wall.

Indexed as

AnimalsBlood VesselsCell DifferentiationEpigenomicsHumansMesenchymal Stem CellsMuscle, Smooth, VascularRegeneration

Identifiers

PMID21293008
PMCPMC3382110
OpenAlexW2010866973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.