ArticleThe American journal of tropical medicine and hygiene2011
Genetic diversity of polymorphic vaccine candidate antigens (apical membrane antigen-1, merozoite surface protein-3, and erythrocyte binding antigen-175) in Plasmodium falciparum isolates from western and central Africa.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Spatiotemporal analysis of Plasmodium falciparum erythrocyte binding antigen-175 gene dimorphism in Ghana.Malaria journal · 2025Article
- Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomaticFrontiers in immunology · 2025Article
- Genetic diversity of Plasmodium falciparum AMA-1 antigen from the Northeast Indian state of Tripura and comparison with global sequences: implications for vaccine development.Malaria journal · 2022Article
- Article
- Age-dependent carriage of alleles and haplotypes of Plasmodium falciparum sera5, eba-175, and csp in a region of intense malaria transmission in Uganda.Malaria journal · 2020Article
- Hotspots inInternational journal of molecular sciences · 2020Review
- Genetic polymorphism of merozoite surface protein-3 in Myanmar Plasmodium falciparum field isolates.Malaria journal · 2020Article
- Memory B-Cell Responses Against Merozoite Antigens After AcuteFrontiers in immunology · 2020Article
- Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum.BMC bioinformatics · 2019Article
- Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa.BMC genomics · 2018Article
- Unraveling Haplotype Diversity of the Apical Membrane Antigen-1 Gene inThe Korean journal of parasitology · 2018Article
- Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT.Malaria journal · 2018Article
- Genetic diversity of the merozoite surface protein-3 gene in Plasmodium falciparum populations in Thailand.Malaria journal · 2016Article
- Allelic Diversity and Geographical Distribution of the Gene Encoding Plasmodium falciparum Merozoite Surface Protein-3 in Thailand.The Korean journal of parasitology · 2015Article
- Allelic Forms of Merozoite Surface Protein-3 in Plasmodium falciparum Isolates From Southeast of Iran.Jundishapur journal of microbiology · 2014Article
- Genetic structure of Plasmodium falciparum populations across the Honduras-Nicaragua border.Malaria journal · 2013Article
- Anti-malarial IgG subclasses pattern and FcγRIIa (CD32) polymorphism among pregnancy-associated malaria in semi-immune Saudi women.Malaria journal · 2013Article
- Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana.Malaria journal · 2012Article
- Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal.Journal of infection in developing countries · 2012Article
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8 authors.
Funding
Abstract
The malaria vaccine candidate antigens erythrocyte binding antigen 175 (EBA-175), merozoite surface protein 3 (MSP-3), and apical membrane antigen (AMA-1) from Plasmodium falciparum isolates from countries in central and west Africa were assessed for allelic diversity. Samples were collected on filter paper from 600 P. falciparum-infected symptomatic patients in Cameroon, Republic of Congo, Burkina Faso, Ghana, and Senegal and screened for class-specific amplification fragments. Genetic diversity, assessed by mean heterozygosity, was comparable among countries. We detected a clinical increase in eba 175 F-allele frequency from west to east across the study region. No statistical difference in msp-3 allele distribution between countries was observed. The ama-1 3D7 alleles were present at a lower frequency in central Africa than in West Africa. We also detected little to no genetic differentiation among sampling locations. This finding indicates that, at least at the level of resolution offered by restriction fragment length polymorphism analysis, these antigens showed remarkable genetic homogeneity throughout the region sampled, perhaps caused by balancing selection to maintain a diverse array of antigen haplotyes.
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