Evidence map›Paper›PMID 21292846›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011

Temporal complexity in clinical manifestations of lung disease.

Urs Frey, Geoffrey Maksym, Béla Suki

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Fluctuation Analysis of Peak Expiratory Flow and Its Association with Treatment Failure in Asthma.American journal of respiratory and critical care medicine · 2017
    Trial
  2. Review
  3. Observational
  4. Updated Perspectives on the Role of Biomechanics in COPD: Considerations for the Clinician.International journal of chronic obstructive pulmonary disease · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Reduced expiratory variability index (EVI) is associated with controller medication withdrawal and symptoms in wheezy children aged 1-5 years.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Article
  11. Observational
  12. Article
  13. Article
  14. Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet.American journal of respiratory and critical care medicine · 2016
    Article
  15. Article
  16. Article
  17. Article
  18. Imaging for lung physiology: what do we wish we could measure?Journal of applied physiology (Bethesda, Md. : 1985) · 2012
    Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Urs FreyUniversity Children's Hospital of Basel, 4031 Basel, Switzerland. urs.frey@ukbb.ch
Geoffrey Maksym
Béla Suki

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we summarize results of recent research on the temporal variability of lung function, symptoms, and inflammatory biomarkers. Specifically, we demonstrate how fluctuation analysis borrowed from statistical physics can be used to gain insight into neurorespiratory control and complex chronic dynamic diseases such as asthma viewed as a system of interacting components (e.g., inflammatory, immunological, and mechanical). Fluctuation analysis tools are based on quantifying the distribution and the short- and long-term temporal history of tidal breathing and lung function parameters to assess neurorespiratory control and monitor chronic disease. The latter includes the assessment of severity and disease control, the impact of treatment and environmental triggers, the temporal characterization of disease phenotypes, and the individual risk of exacerbation. While in many cases specific mechanistic insight into the fluctuations still awaits further research, appropriate analyses of the fluctuations already impact on clinical science and practice.

Indexed as

LungLung DiseasesPeriodicityRespirationSystems BiologyAnimalsDisease ProgressionFractalsHomeostasisHumansInflammation MediatorsPhenotypePrognosisSeverity of Illness IndexSystems IntegrationTime FactorsInflammation Mediators

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.