ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011
Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD.Physiological reports · 2019Trial
- Comparison of limited driving pressure ventilation and low tidal volume strategies in adults with acute respiratory failure on mechanical ventilation: a randomized controlled trial.Therapeutic advances in respiratory diseaseTrial
- Deciphering the Pathogenic Cascade of Acrolein-Induced Lung Injury: From Molecular Insult to Organ Failure.Journal of applied toxicology : JAT · 2026Article
- Effect of airway constriction on ventilation inhomogeneity: multiple-breath washout indices and intrapulmonary reverse flow.Respiratory research · 2026Article
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Lung ultrasound detects regional aeration inhomogeneity in ventilated preterm lambs.Pediatric research · 2024Article
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Targeted Versus Continuous Delivery of Volatile Anesthetics During Cholinergic Bronchoconstriction.Journal of engineering and science in medical diagnostics and therapy · 2018Article
- Functional respiratory imaging, regional strain, and expiratory time constants at three levels of positive end expiratory pressure in an ex vivo pig model.Physiological reports · 2016Article
- Hyperpolarized 3He magnetic resonance imaging ventilation defects in asthma: relationship to airway mechanics.Physiological reports · 2016Article
- Effect of tidal volume and positive end-expiratory pressure on expiratory time constants in experimental lung injury.Physiological reports · 2016Article
- Volatile Anesthetics and the Treatment of Severe Bronchospasm: A Concept of Targeted Delivery.Drug discovery today. Disease models · 2015Article
- Mechanical interactions between adjacent airways in the lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Effects of lung inflation on airway heterogeneity during histaminergic bronchoconstriction.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Influence of cheek support on respiratory impedance measured by forced oscillation technique.SpringerPlus · 2013Article
- Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation.American journal of respiratory cell and molecular biology · 2012Article
- What can computed tomography and magnetic resonance imaging tell us about ventilation?Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
- Constant-phase descriptions of canine lung, chest wall, and total respiratory system viscoelasticity: effects of distending pressure.Respiratory physiology & neurobiology · 2012Article
- Imaging for lung physiology: what do we wish we could measure?Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
- Simulating ventilation distribution in heterogenous lung injury using a binary tree data structure.Computers in biology and medicine · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
The ability to maintain adequate gas exchange depends on the relatively homogeneous distribution of inhaled gas throughout the lung. Structural alterations associated with many respiratory diseases may significantly depress this function during tidal breathing. These alterations frequently occur in a heterogeneous manner due to complex, emergent interactions among the many constitutive elements of the airways and parenchyma, resulting in unique signature changes in the mechanical impedance spectrum of the lungs and total respiratory system as measured by forced oscillations techniques (FOT). When such impedance spectra are characterized by appropriate inverse models, one may obtain functional insight into derangements in global respiratory mechanics. In this review, we provide an overview of the impact of structural heterogeneity with respect to dynamic lung function. Recent studies linking functional impedance measurements to the structural heterogeneity observed in acute lung injury, asthma, and chronic obstructive pulmonary disease are highlighted, as well as current approaches for the modeling and interpretation of impedance. Finally, we discuss the potential diagnostic role of FOT in the context of therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.