ArticleMolecular endocrinology (Baltimore, Md.)2011
TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- SLPI in Prostate Cancer.Cancers · 2026Review
- Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota.Molecular cancer · 2024Review
- Paradoxical sleep deprivation and restriction promote castration-like effects and local inflammatory responses in male gerbil prostate.Journal of biosciences · 2024Article
- Rate of castration-induced prostate stroma regression is reduced in a mouse model of benign prostatic hyperplasia.American journal of clinical and experimental urology · 2023Article
- TNF Signaling Is Required for Castration-Induced Vascular Damage Preceding Prostate Cancer Regression.Cancers · 2022Article
- TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease.Nature communications · 2022Article
- Eldecalcitol prevents muscle loss by suppressing PI3K/AKT/FOXOs pathway in orchiectomized mice.Frontiers in pharmacology · 2022Article
- Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development.Frontiers in genetics · 2021Review
- Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia.JCI insight · 2020Article
- Role of irisin in androgen-deficient muscle wasting and osteopenia in mice.Journal of bone and mineral metabolism · 2020Article
- Suppressive Role of Androgen/Androgen Receptor Signaling via Chemokines on Prostate Cancer Cells.Journal of clinical medicine · 2019Review
- TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice.Endocrinology · 2016Article
- Secretory leukocyte protease inhibitor is a survival and proliferation factor for castration-resistant prostate cancer.Oncogene · 2016Article
- Opportunities and challenges in combination gene cancer therapy.Advanced drug delivery reviews · 2016Review
- TNF signaling mediates an enzalutamide-induced metastatic phenotype of prostate cancer and microenvironment cell co-cultures.Oncotarget · 2015Article
- Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound.BMC urology · 2015Article
- Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castration-resistant prostate cancer.The Journal of biological chemistry · 2012Article
- Advanced prostate cancer: reinforcing the strings between inflammation and the metastatic behavior.Prostate cancer and prostatic diseases · 2012Review
- Paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology.Prostate cancer · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
TNF, a proinflammatory and immune-regulatory cytokine, is a potent apoptotic stimulus in vitro. However, there have been few examples of a physiologic role for TNF-induced apoptosis in vivo. Here, we describe a novel role for TNF in prostate epithelial cell apoptosis after androgen withdrawal. Employing high-resolution serial magnetic resonance imaging to measure mouse prostate volume changes over time, we demonstrate that the extent of castration-induced prostate regression is significantly reduced in mice null for either the Tnf or Tnfr1 genes but not mice deficient for TNF-related apoptosis-inducing ligand or Fas signaling. Wild-type mice receiving soluble TNF (sTNF) receptor 2 (to bind TNF and block signaling) before castration exhibit an identical reduction of prostate regression. Together, these data indicate that uniquely among known extrinsic death signals, TNF is required for castration-induced prostate regression. Additionally, membrane-bound TNF protein and stromal cell specific TNF mRNA levels increase in rat prostate after castration. This is consistent with a paracrine role for TNF in prostate regression. When injected into the peritoneum of Tnf(-/-) mice at the time of castration, sTNF restores normal levels of prostate regression. However, wild-type mice receiving sTNF in the absence of castration do not exhibit prostate regression, indicating that TNF alone is not sufficient but acts in the context of additional castration-induced signals. These findings support a physiologic role for TNF in prostate regression after androgen withdrawal. Understanding this role may lead to novel therapies for prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.