Evidence map›Paper›PMID 21292760›Full record

Trial reportChest2011

Predictors of symptoms are different from predictors of severe exacerbations from asthma in children.

Ann Chen Wu, Kelan Tantisira, Lingling Li, Brooke Schuemann, Scott T Weiss, Anne L Fuhlbrigge, Childhood Asthma Management Program Research Group

Open access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 7 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Change in FEVChest · 2019
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Article
  9. Prediction of Asthma Exacerbations in Children.Journal of personalized medicine · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Neighborhoods, Caregiver Stress, and Children's Asthma Symptoms.The journal of allergy and clinical immunology. In practice · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ann Chen WuCenter for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA; Department of Pediatrics, Children's Hospital, Boston, MA; Harvard Medical School, Department of Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: ann.wu@childrens.harvard.edu.
Kelan TantisiraHarvard Medical School, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Lingling LiCenter for Child Health Care Studies, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA; Harvard Medical School, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Brooke SchuemannChanning Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Scott T WeissHarvard Medical School, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Anne L FuhlbriggeHarvard Medical School, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Childhood Asthma Management Program Research Group
Harvard University · USBrigham and Women's Hospital · USHarvard Pilgrim Health Care · US

Funding

ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KOSMISKI, LISA A. · 1985 to 2008
$52.6M
YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMESM01RR000036 · NCRR · WASHINGTON UNIVERSITY · PI NEWCOMER, JOHN W. · 1985 to 2007
$25.4M
ZINC THERAPY FOR SCLERODERMA--PHASE I STUDYM01RR002719 · NCRR · JOHNS HOPKINS UNIVERSITY · PI EARLEY, CHRISTOPHER J · 1986 to 2007
$20.2M
CAMPCS/3U01HL075408 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2003 to 2010
$4.9M
CAMP Continuation Study/Phase 3U01HL075419 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FUHLBRIGGE, ANNE L · 2003 to 2010
$2.0M
CAMP Continuation Study/Phase 3U01HL075409 · NHLBI · ASTHMA, INC. · PI WILLIAMS, PAUL V · 2003 to 2010
$1.6M
CAMP Continuation Study/Phase 3U01HL075417 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ADKINSON, N FRANKLIN · 2003 to 2010
$1.4M
CAMP Contiunation Study/Phase 3U01HL075416 · NHLBI · NATIONAL JEWISH HEALTH · PI SZEFLER, STANLEY J. · 2003 to 2010
$1.4M
CAMP Continuation Study/Phase 3U01HL075415 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZEIGER, ROBERT S · 2003 to 2010
$1.3M
CAMP Continuation Study/Phase 3U01HL075232 · NHLBI · WASHINGTON UNIVERSITY · PI STRUNK, ROBERT · 2003 to 2010
$1.3M
CAMP Continuation Study/Phse 2 (CAMPCS/2)U01HL075420 · NHLBI · UNIVERSITY OF NEW MEXICO · PI RAISSY, HENGAMEH H · 2003 to 2010
$1.1M
CAMP Continuation Study/Phase 3U01HL075407 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI GRASEMANN, HARTMUT · 2003 to 2010
$1.0M
NCRR NIH HHS M01 RR000036NCRR NIH HHS M01 RR000051NCRR NIH HHS M01RR00051NCRR NIH HHS M01 RR002719NCRR NIH HHS M01RR0099718-24NCRR NIH HHS M01RR02719-14NCRR NIH HHS RR00036NHLBI NIH HHS K08 HL088046NHLBI NIH HHS N01 HR016044NHLBI NIH HHS N01-HR-16044NHLBI NIH HHS N01-HR-16045NHLBI NIH HHS N01-HR-16046NHLBI NIH HHS N01-HR-16047NHLBI NIH HHS N01-HR-16048NHLBI NIH HHS N01-HR-16049NHLBI NIH HHS N01-HR-16050NHLBI NIH HHS N01-HR-16051NHLBI NIH HHS N01-HR-16052NHLBI NIH HHS U01 HL075232NHLBI NIH HHS U01HL075232NHLBI NIH HHS U01 HL075407NHLBI NIH HHS U01HL075407NHLBI NIH HHS U01 HL075408NHLBI NIH HHS U01HL075408NHLBI NIH HHS U01 HL075409NHLBI NIH HHS U01HL075409NHLBI NIH HHS U01 HL075415NHLBI NIH HHS U01HL075415NHLBI NIH HHS U01 HL075416NHLBI NIH HHS U01HL075416NHLBI NIH HHS U01 HL075417NHLBI NIH HHS U01HL075417NHLBI NIH HHS U01 HL075419NHLBI NIH HHS U01HL075419NHLBI NIH HHS U01 HL075420NHLBI NIH HHS U01HL075420
6 · The paper itself

Abstract

backgroundAsthma therapy is typically prescribed and titrated based on patient or parent self-report of symptoms. No longitudinal studies have assessed the relationship between symptoms and severe asthma exacerbations in children. The goal of our study was (1) to assess the association of asthma symptoms with severe asthma exacerbations and (2) to compare predictors of persistent asthma symptoms and predictors of severe asthma exacerbations.

methodsThe Childhood Asthma Management Program was a multicenter clinical trial of 1,041 children randomized to receive budesonide, nedocromil, or placebo (as-needed β-agonist). We conducted a post hoc analysis of diary cards that were completed by subjects on a daily basis to categorize subjects as having persistent vs intermittent symptoms. We defined a severe asthma exacerbation as an episode requiring ≥ 3 days use of oral corticosteroids, hospitalization, or ED visit due to asthma based on self-report at study visits every 4 months.

resultsWhile accounting for longitudinal measures, having persistent symptoms from asthma was significantly associated with having severe asthma exacerbations. Predictors of having persistent symptoms compared with intermittent symptoms included not being treated with inhaled corticosteroids, lower FEV(1)/FVC ratio, and a lower natural logarithm of provocative concentration of methacholine producing a 20% decline in FEV(1) (lnPC(20)). Predictors of having one or more severe asthma exacerbations included younger age, history of hospitalization or ED visit in the prior year, ≥ 3 days use of oral corticosteroids in the prior 3 months, lower FEV(1)/FVC ratio, lower lnPC(20), and higher logarithm to the base 10 eosinophil count; treatment with inhaled corticosteroids was predictive of having no severe asthma exacerbations.

conclusionsPatients with persistent symptoms from asthma were more likely to experience severe asthma exacerbations. Nevertheless, demographic and laboratory predictors of having persistent symptoms are different from predictors of severe asthma exacerbations. Although symptoms and exacerbations are closely related, their predictors are different. The current focus of the National Asthma Education and Prevention Program guidelines on the two separate domains of asthma control, impairment and risk, are supported by our analysis.

Indexed as

Administration, InhalationAnti-Asthmatic AgentsAsthmaBronchoconstrictionBronchodilator AgentsBudesonideChildDose-Response Relationship, DrugDrug Therapy, CombinationFemaleFollow-Up StudiesForced Expiratory VolumeHumansMaleNedocromilPrognosisAnti-Asthmatic AgentsBronchodilator AgentsBudesonideNedocromil

Identifiers

PMID21292760
PMCPMC3130529
OpenAlexW2138043068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.